Chheda et al. have identified an HLA-A2–restricted CD8+ T cell epitope encompassing the H3.3K27M mutation and a corresponding TCR that specifically recognizes the H3.3K27M epitope in glioma cells. These data establish a preclinical basis for T cell–based therapy for HLA-A2+ patients with H3.3K27M+ glioma.

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Organic electrode materials play a crucial role in environmentally friendly and sustainable lithium-ion batteries (LIBs) due to their abundance, high theoretical capacity, inexpensiveness, and recyclability. However, critical issues such as fewer redoxactive sites and poor structural stability limit their extensive application in LIBs. Herein, a unique covalent organic framework (Tp-Azo-COF) with a dual active site of NN and CO is designed and successfully applied as the anode material for LIBs. Benefiting from its abundance of active sites, large conjugate structure, large surface area, and accessible Li + transport channels, the Tp-Azo-COF anode materials present high electrochemical kinetics and structural stability. The assembled LIBs deliver a specific capability of 305.97 mAh g −1 at a current density of 1000 mA g −1 after 3000 cycles. This work may inspire avenues for the development of advanced organic materials of inexpensive, sustainable, and durable rechargeable batteries.