For the past 50 years the pterional craniotomy has been the standard approach for anterior circulation aneurysms. However, this is a major procedure. As the trend is towards minimally invasive surgery generally, we have been developing a minimally invasive approach for anterior circulation aneurysms - the supraorbital microcraniotomy. We present first 50 patients who underwent this operation after an aneurysmal subarchnoid haemorrhage. The data were collected prospectively between 2001 and 2004. A total of 60 aneurysms were clipped (10 patients had two aneurysms). Forty-one of fifty patients (82%) were good grade (WFNS I and II) and 9/50 (18%) were poor grade (WFNS III - V) at the time of surgery. Anterior communicating aneurysms were the commonest (37%), but aneurysms at all of the usual anterior circulation sites were included, apart from ophthalmic aneurysms, as none presented during this period, and pericallosal aneurysms, which were not appropriate for it. Five patients (10%) also had an intracerebral haematoma on presentation. The overall management mortality for this series was 3/50 (6%) with 82% achieving a favourable outcome on the Glasgow Outcome Scale (GOS). For those in good grade at surgery, the mortality was 1/41 (2.4%) with 87.7% achieving a favourable outcome on the GOS.
Background-Over the last 10 years there has been a fourfold increase in cases of tuberculosis in Harare, Zimbabwe. The use of molecular epidemiology to understand tuberculosis transmission in this epidemic has been hampered by the availability of suitable culture facilities. A study was therefore undertaken to explore the potential of spoligotyping, a polymerase chain reaction based technique that does not require tuberculosis culture. Methods-Adults attending a chest clinic with clinical or radiological pulmonary tuberculosis and one smear positive sputum were enrolled over one month. Demographic, socioeconomic, and clinical data were gathered using a standardised questionnaire. Molecular fingerprinting of genomic DNA recovered from sputum was performed by spoligotyping. Results-Sixty one subjects (median age 28 years (range 18-73); 61% men) were recruited and 57 provided adequate sputum samples. Recent rural-urban migration or immigration was not common; 40% of subjects lived in crowded living conditions. DNA suitable for spoligotyping was recovered from 28 patients and 20 diVerent genotypes of Mycobacterium tuberculosis were identified. Fifteen patients were infected with an M tuberculosis strain shared by one or more individuals. Patients infected with a shared spoligotype were not closely linked geographically within Harare, but were more likely to live in overcrowded conditions (69% versus 23%; odds ratio 6.85 (95% CI 1.2 to 47), p = 0.026). Analysis of the patients' original rural family homes revealed two geographically related spoligotype clusters. Conclusions-Spoligotyping may yield valuable molecular typing information in populations where tuberculosis culture is not available. This novel technique requires further development and evaluation in larger epidemiological studies. (Thorax 1998;53:346-350)
Advancing age is known to be a determinant of outcome in head injury. We have sought to discover whether there has been any change in the outcome of elderly patients with severe head injury in Newcastle, where these patients have continued to be treated with maximum intervention. A review of prospectively collected data from the Newcastle Head Injury Database for the period 1990 to 2000 was carried out. All patients aged 70 years and above who had sustained a severe head injury (Glasgow Coma Score of 8 or less from the outset) were included. The Glasgow Outcome Score (GOS) was determined at 6 months. Seventy-one patients were identified. Fifty-seven (80%) died and 2 (3%) were in a vegetative state, 11 (16%) had severe disability, 1 (1%) had moderate disability and no patients made a good recovery. The natural history of this condition remains unchanged and due consideration should be given to this when evaluating interventions for elderly patients with a severe head injury.
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