The adaptive fuzzy vibration control problem of large flexible truss with Hexapod active interface is studied. Firstly, independent modal space model of flexible truss with Hexapod active interface is established with energy method. A stable direct adaptive fuzzy controller is designed based on fuzzy control theory and classical adaptive control theory. Finally, flexible truss active vibration control simulation is conducted. The results show that the adaptive fuzzy controller is effective in both instantaneous excitation and mixing frequency periodical excitation as well as the kinematics parameters of Hexapod are all in the allowable ranges of the actual prototype.