Seizures are caused by the brain's uncontrollable spontaneous stimulation and inhibition. Life-threatening seizures have been linked to whole-body trimmers and inelastic starching of lum-ber muscles. The length of an episodic attack closely relates to the disease's severity. The de-velopment of therapeutic operations for epilepsy in the twenty-first century was explored in this systemic review. The Medline, PubMed, Embase, Cochrane Library, and Web of Science databases were used to gather the data. The systematic search included the following key-words: "Surgical therapy, therapeutic approaches, Developmental approach in treatment, Epi-lepsy, neurological problems, and seizure attack." Eleven of the 120 articles and reviews that were gathered met the inclusion-exclusion criteria. With the introduction of new antiepileptic medications with distinctive modes of action, epilepsy research has expanded. Due to the ex-tensive amount of ongoing epilepsy and more general neuroscience research, as well as the numerous novel chemicals that are now being discovered, the pharmacotherapy of epilepsy is expected to undergo considerable modifications in the ensuing ten years. The study demon-strated that neuromodulation using minimally invasive techniques can help to replace the widely opening resection procedure, which has already been established and shown to be ef-fective in halting the progression of disease, but will have an adverse effect on brain function. The current study concludes that neuromodulation using only minimally invasive techniques aids in replacing the widely opening resection technique which could result in functional im-pairment of brain.