Combination therapy may be unavoidable and common way for the treatment of disease where two or more drugs are given concurrently. The drugs may exhibit effects independently or may interfere with each other. Metformin is an anti-diabetic drug and diclofenac is a NSAID. The in vitro interaction of metformin with diclofenac was studied at room temperature and at different pH conditions. The studies were performed by various UV-Visible spectrophotometric, conductometric and HPLC methods. It was found that metformin formed stable 1:1 complex with diclofenac. The interaction may greatly influence the activity of these molecules.

The purpose of the present study was to investigate the in vitro complex formation and to study the nature and strength of complexes which could be formed due to interaction of metformin with ibuprofen. Metformin is an antidiabetic drug and ibuprofen is a non steroidal anti-inflammatory drug (NSAID). The in vitro interaction of metformin with ibuprofen was studied at room temperature and at different pH conditions. The studies were performed by UV-Visible spectrophotometry, conductometry and reversed -it was phase high performance liquid chromatography (RP-HPLC). It was found that metformin formed stable 1:1 complex with ibuprofen. The interaction may greatly influence the activity of these molecules.