With the accelerating process of world industrialization, countries pay more attention to industrial modernization. In order to solve the problems of traditional control technology and system with low accuracy, high energy consumption, and high delay in industrial automation control and the difficulty in adapting to the new industrial production process, the new industrial automation control system is discussed and studied. The industrial automation control is studied, and a new monitoring system is designed for automation control by using ZigBee wireless communication technology. The design of the system data communication scheme is completed by the in-depth study and summary of ZigBee wireless communication technology. The hardware structure and software structure of ZigBee wireless communication module are designed, and the wireless monitoring system using ZigBee is established. Taking the production workshop of a pharmaceutical factory as the monitoring object, the working stability and data transmission efficiency of the model are tested. The experiment shows that the ZigBee wireless transmission model has lower temperature and better stability than the wired transmission system in the working process. Compared with the traditional wired control system, the temperature of ZigBee wireless control system is lower when it works. The difference between the highest temperature and the lowest temperature is 0.1°C. In the overall work flow, the system temperature is lower than that of the wired control. ZigBee wireless control has good stability. Subsequently, the method of manually setting obstacles is used to test the effectiveness of data transmission. The experiment found that in the absence of barrier, the maximum effective transmission distance was 40 meters, and the packet loss rate was very low, which could ensure the timeliness of data. Therefore, this system can be applied to industrial automation control. The research results can provide some reference for the design of new control systems in other industrial control fields. The improved system can also be applied to other industries. ZigBee is a short-range technology for wireless sensor networks, and it is a two-way communication technology with low power consumption, low data rate, and low cost. It can be applied to automatic control and remote control. This provides a platform for wireless networking and control of small and cheap devices. ZigBee will not compete with connection technologies such as Wi-Fi. Meanwhile, it will greatly stimulate the progress of the industrial market.