Owing to the competitive advantages of fast response speed, large pushing force, high reliability, and high precision, the permanent magnet linear synchronous motor (PMLSM) has played an increasingly vital role in various high-speed and high-precision control systems. However, PMLSM exhibits nonlinear behavior in actual operation, and position tracking precision is negatively affected by friction, load changes, and other external disturbances. To meet the growing demand and solve the position tracking control problem for the PMLSM, the control system is critical. Sliding-mode control (SMC) has been used extensively in nonlinear control systems due to its superior performance characterized by simplicity, good dynamic response and insensitivity to parameter perturbation and external disturbances, and has been implemented in PMLSMs to track practical position. The objective of this article is to classify, scrutinize and review the major sliding-mode control approaches for position control of PMLSM. The three different conventional SMC methods, namely the boundary layer approach, the reaching law approach and the disturbance observer-based SMC, are discussed in detail. The four advanced forms of SMC, namely terminal SMC, super-twisting SMC, adaptive SMC and intelligent SMC, are also presented. A comparison of these approaches is given, in which the advantages and disadvantages of each approach are presented; additionally, they are presented in table form in order to facilitate reading. It is anticipated that this work will serve as a reference and provide important insight into position control of PMLSM systems.

Introduction Hyperoside (HYP), a flavonol glycoside compound, has been shown to significantly inhibit the proliferation of malignant tumors. Mitochondria serve as both “energy factories” and “suicide weapon stores” of cells. Targeted delivery of cytotoxic drugs to the mitochondria of tumor cells and tumor vascular cells is a promising strategy to improve the efficacy of chemotherapy. Objective We report a novel dual-functional liposome system possessing both extracellular charge reversal and mitochondrial targeting properties to enhance drug accumulation in mitochondria and trigger apoptosis of cancer cells. Methods L-lysine was used as a linker to connect 2,3-dimethylmaleic anhydride (DMA) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) to yield a new compound, DSPE-Lys-DMA (DLD). Then, DLD was mixed with other commercially available lipids to form charge reversed and mitochondria-targeted liposomes (DLD-Lip). The size, morphology, zeta potential, serum stability, and protein adsorption of the HYP loaded DLD-Lip (HYP/DLD-Lip) were measured. The release profile, cellular uptake, in vitro and in vivo toxicity, and anticancer activity of HYP/DLD-Lip were investigated. Results The results showed that the mean diameter of the liposomes was less than 200 nm. The zeta potential of the liposomes was negative at pH 7.4. However, the zeta potential was positive at weak acidic pH values with the cleavage of the DMA amide. The charge reversion of HYP/DLD-Lip facilitated the cellular internalization and mitochondrial accumulation for enhanced antitumor effect. The strongest tumor growth inhibition (TGI 88.79%) without systemic toxicity was observed in DLD/HYP-Lips-treated CBRH-7919 tumor xenograft BALB/C mice. Conclusion The charge reversed and mitochondria-targeted liposomes represented a promising anticancer drug delivery system for enhanced anticancer therapeutic efficacy.

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Since permanent magnet linear synchronous motors are widely used in fatigue testing, in this paper, the thrust of a permanent magnet linear synchronous motor (PMLSM) is amplified more than 10 times by the method of resonance. Firstly, the air gap magnetic field is analyzed by the equivalent magnetization current method (EMC), the electromagnetic thrust is calculated, and the expression is given by the Maxwell tensor method. The vibration analysis of the whole machine is used to obtain the conditions under which the motor resonates. The dynamic and static characteristics of the motor are analyzed through finite element simulation, the results of the motor design are judged to be reasonable, and the theoretical calculation results are compared with the simulation results to verify the accuracy of the theoretical calculation. The accuracy of the simulation results is verified by static force experiments. Finally, the rated thrust of the motor was enlarged more than 10 times by resonance experiments.