The main aim of root canal therapy is the removal of microbial contaminants in conjunction with the total closure of the root canal system. Root canal sealers along with solid core material plays a major role in achieving the three-dimensional sealing of the root canal system. These sealers are binding agents which are used to adapt the rigid gutta-percha to canal walls and to fill up the voids, accessory canals and irregularities within the canal. Root canal sealers, although used only as adjunctive materials in the obturation of root canals, have been shown to influence the outcome of endodontic treatment. A perfect combination of sealing ability and biocompatibility is what an ideal root canal sealer should possess. This article discusses the current concepts in the usage of different sealers in endodontic therapy and their comparison in order to draw some clinical inferences.