Acrylamide (AA), an industrial compound, causes reproductive toxicity in female rats due to oxidative stress. In the present study, we investigated the protective effects of Curcumin (Cur) against acrylamide-induced ovarian toxicity in female rats. The animals utilized in this study were divided into 4 groups: GI-Control group received a daily oral administration of 0.5ml DMSO (1%) saline (9%), GII-Acrylamide (AA) group received acrylamide (20 mg/kg b.w.) for 21days, GIII-Acrylamide + Curcumin (AA + Cur) group treated with Curcumin (100 mg/kg b.w.) after acrylamide intoxication for 21 days, GIV-Curcumin (Cur) group that received only Curcumin (100 mg/kg b.w.). In our study, we observed acrylamide intoxication to be associated with a significant (P<0.05) increase in the serum levels of estradiol, luteinizing hormone (LH), testosterone (T), and tumor marker CA125 and CEA. The mean values of serum progesterone (P4), follicle-stimulating hormone (FSH), and total antioxidant capacity (TAC) significantly decreased in the AA-treated group as compared to the control. Histological investigations revealed that AA treatment results in an apparent regression of ovarian follicles, cyst formation, and corpus luteum degeneration. Treatment with curcumin restored altered ovarian histology and serological indices concomitantly to normal

Background: Acrylamide was well known to induce oxidative stress with an impact on reproductive functions on both male and female. Taurine is a potent antioxidant. This study was conducted as a trail to abrogates acrylamide induced reproductive toxicity in female rats by administration taurine. Animals were divided into 4 groups (N= 10); Control group kept on balanced diet and saline (9%), Acrylamide (AA) group received acrylamide in drinking water (20 mg/kg b.w.) for 21days and acrylamide + taurine (AA+TA) treated with taurine (50 mg/kg b.w.) after acrylamide intoxication for 21 days and taurine (TA) group received taurine (50 mg/kg b.w.). Hormonal, antioxidants and tumor markers (CA125 and CEA) were assayed and correlated with histological changes in ovarian tissue. Results: Administration of acrylamide produced significant increase in serum levels of estradiol, LH, testosterone and in tumor markers CA125 and CEA. Whereas those of progesterone, FSH and total antioxidant capacity (TAC) were significantly reduced. Histological study showed that AA result in apparent regression of ovarian follicles and corpus luteum degeneration and cyst formation. Treatment with taurine restored altered ovarian histology and serological indices concomitantly towards normal levels. In conclusion: Results revealed that taurine is able to significantly alleviate the reproductive toxicity induced by AA in female rats via modulating oxidative stress and could be utilized as a potent diatry supplementation.