This study was carried out to determine the curative effect of aqueous stem bark extract of Erythrina mildbraedii in rats induced with nephrotoxicity using 800mg/kg Acetaminophen. Acetaminophen administration resulted in significant increase in the serum level of urea, creatinine, Na

The ethnopharmacological uses of shea butter provides an evidence of its uses in our dishes and has been a tradition in many West African continent. This may be related due to it higher nutritional values, phytochemical content etc hence make it's a valuable material in African folk medicine. This study is aimed to evaluate the phytochemicals, proximate and physicochemical analysis of Shea Butter. The AOAC protocols were followed for the proximate and physicochemical analyses, whereas the Brain and tuner techniques were used for the qualitative phytochemical study. The qualitative phytochemical analysis reveals the presence of various phytochemicals such as Terpenoids, Alkaloids, Saponins, Flavonoids, Tannins and Cardiac glycosides, the proximate analysis shows the percentage composition of Moisture (1.233±0.033), Ash (0.090 ± 0.0), Protein (3.103 ± 0.023), Fat (92.91±0.069) and Carbohydrate (2.660 ± 0.098), whereas the Physicochemical analysis shows the Physical and Chemical parameters as; Slip point 0 C (68.67±0.67), Clear point 0 C (119.3 ± 0.66), Smoke point 0 C (162.0 ± 1.155), Flash point 0 C (198.7±0.67), Fire point 0 C (302.0 ± 1.155), Specific gravity (0.856±0.001) Refractive Index @25 0 C (1.531 ± 0.003), Free fatty acid Value (0.533 ± 0.0067), Saponification Value (186.9 ± 0.073) Iodine Value (30.78 ± 0.012), Peroxide Value (0.9367±0.012). The findings revealed that, the Shea butter contained certain phyto-constituents and it physicochemical parameters fulfilled the FOA/WHO criteria. Similarly, shea butter contains some nutritionally significant components and has health benefits in addition to its numerous industrial applications.

No abstract

This study evaluated the curative effects of aqueous stem bark extact of Erythrina mildbraedii in CCL 4 induced liver damage. With the exception of group 1 (positive control), CCL 4 was administered at a dose of 150 mg/kg to groups II, III, IV and V.Administration of CCL 4 caused profound hepatic damage as indicated by elevation in serum levels of liver transaminases, alkaline phosphatase, total and direct bilirubin. There was depletion of serum proteins and albumin. Administration of aquoeus stem bark extract of Erythrina mildbraedii at daily oral doses of 50,100, 150mg/kg reversed these biochemical aberrations to a significant level. The curative effects of stem bark extracts of Erythrina mildbraedii were further substantiated by histopathological examination of the liver hepatocytes . The result of the study suggested that aqueous stem bark extract of Erythrina mildbraedii posses hepatocurative effects.