A Pd/C and TFA-promoted effective one-pot synthesis of oxepines starting from iodoheteroaryl/aryl ethers and terminal alkyne has been developed under mild conditions. This transformation involves intermolecular CÀ C bond formation between the aryl iodide and terminal alkynes followed by intramolecular hydroarylation of alkyne, affording the desired oxepines in good yields. A possible mechanism was proposed.
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