A BSTRACT Purpose: Osteoporosis is especially prevalent in the older population and in women. Fractures lead to many health complications, placing an enormous burden on the health system. Improved knowledge will encourage healthy practices that prevent osteoporosis and help community members avoid unhealthy lifestyles and habits. The goal of this study was to evaluate the knowledge, attitudes, and practices relating to osteoporosis among male and female students of the Jazan community. Methods: The Jazan region has 13 governorates and a population of more than 1.5 million. For this study, 440 participants were selected from seven different governorates, and the osteoporosis knowledge assessment tool (OKAT) was used together with five background variables and some questions on attitude and practice. A Chi-squared test was implemented to identify any significant relationships between the background variables and the knowledge and practice scores. A P value of less than 0.05 was considered significant. Results: Of the 440 participants, 53% were men and 47% women. Thirty-three percent of them held government jobs, 73% had completed university, and 50% had a monthly income of less than 5,000 riyals. Regarding the risk factors for osteoporosis, 62 (14%) smoked, 37 (8.4%) used steroids, 184 (41.8%) had a family history of osteoporosis, and 393 (89.3%) had not attended an education campaign on osteoporosis. The highest number of correct answers in the OKAT was to the question “osteoporosis increases the risk of fractures” (423, 96.1%), and the lowest number of correct answers was to the question “osteoporosis is more common in men” (60, 13.6%). Regarding protective behaviors against osteoporosis, namely physical activity, daily intake of dairy products, attending an education campaign, and background characteristics, attending an education campaign was statistically significant, with a P value of 0.003, but marital status, education level, body mass index (BMI), and occupation were not statistically significant. For the risk factors, sex was statistically significant, along with the daily soft drink intake and smoking but not with the use of steroids. Other background characteristics, such as education level and BMI, were not statistically significant as osteoporosis risk factors. Conclusions: The participants’ level of knowledge was high, and the risk factors for osteoporosis were still present together with a low level of achievement for protective measures. It is highly recommended that education campaigns be implemented to increase knowledge and encourage improved attitudes and practices.