Objective
To describe various infectious triggers for Kawasaki disease (KD) in India.
Methods
A series of 10 children with diagnosed infections who developed KD during their course of illness has been presented. They were diagnosed by the American Heart Association (AHA) 2017 guidelines. Echocardiography was done to check for coronary artery dilation. Treatment was instituted as per standard protocol.
Results
Kawasaki disease was diagnosed in 8 boys and 2 girls, aged 1 mo to 11 y. These children were being treated for dengue, chikungunya, SARS-CoV-2, hepatitis A, tuberculosis, brucellosis, disseminated staphylococcal sepsis, scrub typhus, and enteric fever.
Conclusions
Kawasaki disease has been associated with infectious triggers. It should be considered in febrile patients with mucocutaneous involvement or in nonresponsive sepsis, despite adequate therapy.
Objective: A cluster-randomized trial of home-based care using primary care resources for people with epilepsy has been set up to optimize epilepsy care in resource-limited communities in low-and middle-income countries. The primary aim is to determine whether treatment adherence to antiepileptic drugs is better with home-based care or with routine clinic-based care. Secondary aims are to compare the effects of the two care pathways on seizure control and quality of life.Methods: The home-based intervention comprises epilepsy medication provision, adherence reinforcement, and epilepsy self-management and stigma management guidance provided by an auxiliary nurse-midwife equivalent. The experimental group will be compared with a routine clinic-based care group using a cluster-randomized design in which the unit of analysis is a cluster of 10 people with epilepsy residing in an area cared for by a single accredited government grass-root health worker. The primary outcome is treatment adherence as measured by monthly tablet counts and two self-completed questionnaires. The secondary outcomes include monthly seizure-frequency, time to first seizure (in days) after enrolment, proportion of subjects experiencing seizure freedom for the duration of the study and quality of life measured by the "Personal Impact of Epilepsy Scale," all assessed by an independent study nurse.Results: The screening phase and neurological evaluations and randomizations have been recently completed and follow-up is currently underway.
Conclusion:The Results of the trial are likely to have substantial bearing on the development of governmental policies and strategies to provide coverage and care for epilepsy in resource-limited countries.
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