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Natural mucilages are auspicious biodegradable polymeric materials. The aim of the present research work was to elucidate the characteristics of quince mucilage-based polymeric network for sustained delivery of metprolol tartrate and its toxicity evaluation. Mucilage was extracted by hot water extraction, and characterization of quince mucilage was accomplished by using Fourier transform infrared (FTIR) spectroscopy. Different batches of quince mucilage polymeric network were prepared by free radical polymerization by utilizing varying ratios of quince mucilage, acrylamide and crosslinker. Degree of swelling depends on concentration of mucilage, monomer and also on crosslinking density of polymeric network. FTIR illustrates proficient grafting, and morphological (scanning electron microscopy) analysis signified porous design. Hence, quince mucilage-based design was encouraging for sustained delivery of metprolol tartrate and acute toxicity evaluation proved that mucilage-based network was safe for oral drug delivery system.

The present study was conducted to fabricate and characterize mucilage-based polymeric networks of Aloe vera for controlled drug release. Aloe vera mucilage was used to develop a polymeric network via the free-radical polymerization method using potassium persulphate as the initiator, N′ N′-Methylene bisacrylamide as the crosslinker, and acrylamide as the monomer. Using varying concentrations of Aloe vera mucilage, crosslinker, and monomer, we developed different formulations. Swelling studies were conducted at pH 1.2 and 7.4. Concentrations of polymer, monomer, and crosslinker were optimized as a function of swelling. Porosity and gel content were calculated for all samples. FTIR, SEM, XRD, TGA, and DSC studies were conducted for the characterization of polymeric networks. Thiocolchicoside was used as a model drug to study the in vitro release in acidic and alkaline pH. Various kinetics models were applied by using a DD solver. Increasing content of monomer and crosslinker swelling, porosity, and drug release decreased while gel content increased. An increase in Aloe vera mucilage concentration promotes swelling, porosity, and drug release of the polymeric network but decreases gel content. The FTIR study confirmed the formation of crosslinked networks. SEM indicated that the polymeric network had a porous structure. DSC and XRD studies indicated the entrapment of drugs inside the polymeric networks in amorphous form. The analytical method was validated according to ICH guidelines in terms of linearity, range, LOD, LOQ, accuracy, precision, and robustness. Analysis of drug release mechanism revealed Fickian behavior of all formulations. All these results indicated that the M1 formulation was considered to be the best polymeric network formulation in terms of sustaining drug release patterns.

Since government regulations have forced manufacturers to minimise volatile organic compounds and consumer trends drive the demand for environmentally friendly products, polyurethane formulations have shifted away from solvent-based polyurethane formulations toward aqueous polyurethane dispersions. Because of the current need in this work, a renewable canola oil-based polyol derived from canola oil was synthesised by the epoxidation and oxirane ring-opening procedure and polymerized with different diisocyanates, dimethylol propionic acid, and 1,4-butanediol, used to produce waterborne PU dispersion. The structural characterization of the prepared polyol and dispersions was carried out by FTIR spectroscopy. The synthesised dispersions were applied to the poly/cotton fabrics by the pad-dry-cure process and their textile performances, such as pilling resistance and color fastness properties, were investigated. The antibacterial activity of the finished applied fabrics was also evaluated against gram-positive and gram-negative bacteria. All the samples have shown remarkable enhancement in both anti-pilling (1/2 to 3/4 in dyed) and color fastness properties (such as rubbing in dyed, dry 3/4 to 4/5, and wet 3 to 4) as the solution concentration of the dispersions increases. The results reveal that canola oil-based PU dispersions applied as a finish to the poly/cotton fabrics enhanced their textile as well as antibacterial performance.