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The well-defined unnatural dipeptides based on cis-2,5-disubstituted pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(-)-1-phenylethylamine, and phenylalanine. The configurations of all the chiral centers in these unnatural dipeptides are confirmed by X-ray crystal diffraction analysis.

The investigation of the electrogenerated free radical of morin reacting with an oxidant is helpful in understanding its antioxidant pharmacology. In phosphate buffer (pH 5.6 ± 0.1), the reduction of morin proceeds with a one-electron transfer of the C=O double bond into a free radical intermediate, which then delivers the final primary alcohol via a one-electron reduction. When an oxidant KIO3 is present, the free radical intermediate of morin is oxidized to regenerate the original ‘C=O’ bond. Further reduction processes are effectively inhibited, resulting in a sensitive catalytic peak, with the peak current enhanced 70 times.

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