The organometallic compounds are prospective candidates in the row of developing metallochemotherapeutics with the aim of overcoming the limitations of platinum drugs. In order to explore the anticancer properties of organometallic compounds with the natural medicines, two Ru­(II)-p-cymene complexes containing the natural products, viz., 6-gingerol (6G) and benzylated-6-gingerdione (B-6GD) have been synthesized and characterized well. The phenolic group of the Ru­(6G) complex facilitates its higher cell-free antioxidant activity than its analogue complex. Also, the same complex shows higher cytotoxicity toward A549 lung and HeLa-S3 cervical cancer cells than the Ru­(B-6GD) complex but lower cytotoxicity toward A2058 metastatic melanoma cancer cells. Both complexes are shown to easily accumulate in melanoma cancer cells, and their degree of cytotoxicity in the same cells is found to be positively correlated with cell uptake. The cytotoxicity of complexes arises from their intracellular activity, mainly due to the induction of singlet oxygen production in cancer cells. The subcellular fractionation study shows that mitochondria and ER-Golgi membranes might be their predominant targets. Also, the mechanistic investigation revealed that Ru­(B-6GD) induces caspase-dependent non-apoptotic cell death whereas Ru­(6G) can induce caspase-independent non-apoptotic cell death. Furthermore, both complexes are found to moderately alter the adhesion properties of cancer cells, which is beneficial for antimetastatic treatment. Despite the potential pharmacological activity, Ru­(6G) is encapsulated into polymer-supported liposomes to reduce its toxicity and further improve its anticancer potency. The π-conjugated yne–ene chain of polydiacetylene aids in the development of a stable nanoformulation, which achieved a slow release of the complex. Most importantly, the cancer cell uptake of the liposome-encapsulated Ru­(6G) complex is 20 times enhanced and the total ROS formation in cancer cells is significantly increased compared to the non-encapsulated complex. However, the nanoformulation does not alter the antimetastatic potency of the encapsulated complex.

In this study, we report the first application of (4-(tert-butyl) benzyl or 4-methyl benzyl)-substituted 2-(pyridin-2-yl)-1Hbenzo[d]-imidazole coordinated copper and cobalt redox shuttles Cu [((tbb) pbi) 2 ] + 1/ + 2 , Cu [(mbpbi) 2 ] + 1/ + 2 , Co [((tbb) pbi) 3 ] + 2/ + 3 and Co [(mbpbi) 3 ] + 2/ + 3 based xanthan gum gel electrolytes (XGE-1, XGE-2, XGE-3 and XGE-4) in fabrication of Dye sensitized solar cells. Interestingly, XGE-1 and XGE-2 obtained higher efficiency of 4.08 and 3.04 % under 1sun illumination. Specifically, highly donor moiety 4-(tertbutyl)benzyl)-substituted (on NÀ H position) 2-(pyridin-2-yl)-1H-benzo[d]-imidazole ligands coordinated, Cu [((tbb) pbi) 2 ] + 1/ + 2 gel electrolyte achieved best performance due to its appropriate redox potential of 0.80 V versus Normal Hydrogen Electrode. This high performance also confirmed with the interfacial studies of the devices. As per the computational results, the copper redox mediators conquered lower reorganization energy and free energy about (0.11-0.20 & 0.18-0.27 eV) due to the effect of ligands structure. Overall, Cu [((tbb) pbi) 2 ] + 1/ + 2 act as redox shuttle for highly proficient DSSCs.

The separation of mixtures of isomers is a daunting task. It is found that perethylated pillar[5]arene can separate trans-dichloroethene from its cis isomer. This work deals with the host-guest interactions...

No abstract

No abstract