The spread of the Severe Acute Respiratory Syndrome (SARS-CoV-2) virus has caused the COVID-19 pandemic for more than a year. Daily cases in Indonesia keep increasing following the high mortality rate, entitling it as the epicentre country of Asia. The government advises patients with mild symptoms to take self-isolation at home. Due to its rich cultures and beliefs in Indonesia, patients on independent isolation tend to take treatment on their own accord, such as using traditional herbal medicine renowned as jamu. This article is aimed to review the use of various types of concoctions in jamu taken as the prevention and additional therapy for COVID-19 patients. The review may advantage for COVID-19 treatment discovery through indigenous compound and medical care in societies. In writing this article, the author collected information from related articles in online sources such as Google Scholar, Pubmed, Science Direct, as well as circulars from the Indonesian Ministry of Health and treatment guidelines from the Food and Drug Supervisory Agency. Polyherbal formulations that have been widely recommended for COVID-19 treatment are 9 jamu formulas within Zingiber officiale for the highest herbal compound used and followed by other 21 herbal plants such as Curcuma zanthorrhiza, Cinnomomun verum, Citrus aurantifolia fruit, Cymbapogon sitratus, Curcuma longa, Alpinea galangal, etc. Five of all founded jamu identified for antivirus agent as well as mostly applied in immune booster tradisionally. Moreover, all of jamu formulas has antioxidant activities and antiinflamatory effect that would be promising for COVID-19 treatment, especially for Jamu Pahitan and Wedang Secang could be the candidates for COVID-19 therapy through increasing immunity and reducing risk factors for each symptom. No antagonistic interactions were found in the herbal concoctions, while several synergistic interactions that increase the pharmacological activity. This study would contribute a remarkable literacy since the use of jamu in preventing and treating COVID-19 as a new disease requires careful consideration due to the limited scientific data and clinical evidence to support its use.