The objective of this study was to perform a meta-analysis of publications that reported the association between dispositional optimism and depression during youth, analyzing if the strength of this relationship varied according to potential factors. Systematic searches were carried out in APA PsycNet, Virtual Health Library, Embase, Web of Science, PubMed Central, and Scopus to collect English, Portuguese, or Spanish studies from 2009 onwards. Two reviewers selected the eligible articles, assessed the quality of each study, and extracted the data. For the synthesis of the results, a meta-analytic approach was used. We identified 4077 publications in the initial searches and 22 in the supplementary searches, from which 31 studies remained for analysis once the eligibility criteria were applied. The results showed a statistically significant negative association between dispositional optimism and depression in the young population, age being a factor that modifies the effect measure between these variables. This meta-analysis provides a consistent and robust synthesis on the interaction effect between dispositional optimism and depression in the young population. Based on these findings, early clinical admissions may effectively improve optimistic tendencies in young people, which could help them prevent depressive symptoms or episodes.

Chronic Social Isolation (CSI) is a model of prolonged stress employed in a variety of studies to induce depression and anxious behavior in rats. The present study aims to evaluate the effect of CSI on male Wistar rats in terms of “anhedonic-type” behavior in the Sucrose Preference Test (SPT) and anxiogenic profile in the elevated-plus-maze (EPM) test, as well as evaluating the effect of resocialization upon sucrose consumption. A total of 24 adolescent male Wistar rats were evaluated. The animals were housed either together (communally) or socially isolated for 21 days, and then exposed for four consecutive days to the SPT test [water vs. a 32% sucrose solution (SS)]. Four days later, they were again subjected to the SPT test (32% vs. 0.7% SS), and then tested on the EPM apparatus 3 days later. Following the completion of the anxiogenic profile of the model, the animals were resocialized for 72 h and then re-tested once again using the SPT (32% vs. 0.7% SS). Twenty-four hours after this final consumption, the animals were euthanized to record the weight of their adrenal glands (AG). It was found that exposure to CSI produces anhedonic-type behavior and an anxiogenic profile in adolescent male rats, as evidenced in both the SPT and EPM tests, as well as in the animals’ physiological stress response. It was also demonstrated that resocialization does not reverse the anhedonic-type behavior, nor the physiological response to stress.

El objetivo del presente estudio fue identificar comorbilidad entre TEPT y TDM en personas víctimas del desplazamiento forzado y factores asociados. Se realizó una investigación de enfoque cuantitativo, diseño no experimental de corte transversal y alcance descriptivo-analítico. Fueron evaluadas 120 personas, de ambos géneros, entre 18 a 57 años, seleccionadas a través de un muestreo no probabilístico por conveniencia. Se utilizó una entrevista clínica estructurada para diagnósticos del Eje I (SCID-I) basada en los criterios del DSM IV para el TEPT y TDM, posterior a la aplicación de un cuestionario de datos sociodemográficos y antecedentes clínicos con el que se registraron los factores de riesgos y síntomas asociados. La prevalencia para TEPT fue del 48%, para TDM del 32% y 21% para comorbilidad, asociada con ideación e intento suicida y síntoma de rumiación. Los resultados fueron discutidos a la luz de otros estudios de prevalencia y la importancia de los factores de riesgo asociados en la comprensión de la comorbilidad entre TEPT y TDM.