Despite intense research, the neural correlates of stroke-induced deficits of spatial cognition remain controversial. For example, several cortical regions and white-matter tracts have been designated as possible anatomic predictors of spatial neglect. However, many studies focused on local anatomy, an approach that does not harmonize with the notion that brain-behavior relationships are flexible and may involve interactions among distant regions. We studied in humans of either sex restingstate fMRI connectivity associated with performance in line bisection, reading and visual search, tasks commonly used for he clinical diagnosis of neglect. We defined left and right frontal, parietal, and temporal areas as seeds (or regions of interest, ROIs), and measured whole-brain seed-based functional connectivity (FC) and ROI-to-ROI connectivity in subacute right-hemisphere stroke patients. Performance on the line bisection task was associated with decreased FC between the right fusiform gyrus and left superior occipital cortex. Complementary increases and decreases of connectivity between both temporal and occipital lobes predicted reading errors. In addition, visual search deficits were associated with modifications of FC between left and right inferior parietal lobes and right insular cortex. These distinct connectivity patterns were substantiated by analyses of FC between left-and right-hemispheric ROIs, which revealed that decreased interhemispheric and right intrahemispheric FC was associated with higher levels of impairment. Together, these findings indicate that intrahemispheric and interhemispheric cooperation between brain regions lying outside the damaged area contributes to spatial deficits in a way that depends on the different cognitive components recruited during reading, spatial judgments, and visual exploration.

Existing measures of breast size dissatisfaction have poor ecological validity or have not been fully evaluated in terms of psychometric properties. Here, we report on the development of the Breast Size Rating Scale (BSRS), a novel measure of breast size dissatisfaction consisting of 14 computer-generated images varying in breast size alone. Study 1 (N=107) supported the scale's construct validity, insofar as participants were able to correctly order the images in terms of breast size. Study 2 (N=234) provided evidence of the test-retest reliability of BSRS-derived scores after 3 months. Studies 3 (N=730) and 4 (N=234) provided evidence of the convergent validity of BSRS-derived breast size dissatisfaction scores, which were significantly associated with a range of measures of body image. The BSRS provides a useful tool for researchers examining women's breast size dissatisfaction.

No abstract