Patients with systemic lupus erythematosus (SLE) experience chronic symptoms that negatively impact their quality of life (QoL). This study analyzed the variables that contributed to QoL in patients with SLE, including the mediating role of psychological morbidity and disease activity. This study used a transversal design and included 104 women with SLE. Participants answered several instruments assessing fatigue, psychological morbidity (depression and anxiety), body image, disease activity, and quality of life. The results showed that disease activity, fatigue severity, psychological morbidity and body image were associated with all domains of QoL. Additionally, psychological morbidity and disease activity mediated the relationship between body image and psychological morbidity. Also, disease activity mediated the relationship between body image and fatigue severity. According to the results, intervention in patients with SLE should focus on patients' psychological morbidity, particularly in the active phase of the disease. Body image, fatigue severity and psychological morbidity should be monitored in patients with SLE in order to promote QoL.
The use of daratumumab in combination with established regimens for the treatment of newly diagnosed multiple myeloma has recently been authorized by the European Medicines Agency based on results from three separate phase III randomized, active controlled, open-label studies that have confirmed enhanced efficacy and tolerability in both transplant-ineligible (MMY3008 and MMY3007) and transplant-eligible (MMY3006) patients, without compromising transplant ability. Trial MMY3008 showed an improvement in progression-free survival (PFS) when daratumumab was added to lenalidomide and dexamethasone compared with lenalidomide and dexamethasone; the median PFS had not been reached in the daratumumab arm and was 31.9 months in the control arm (hazard ratio [HR], 0.56; 95% confidence interval [CI], 0.43-0.73; p < .
RESUMO:O principal objectivo deste estudo foi realizar a adaptação da Escala da Intensidade da Fadiga (Krupp et al., 1989), que visa avaliar a percepção do nível de fadiga em doentes com Lúpus Eritematoso Sistémico (LES). Os resultados, numa amostra de 104 doentes com LES, ao nível da análise factorial revelaram que os itens da versão original se organizam exactamente num único factor, de acordo com o modelo original. Em termos de fidelidade, o coeficiente encontrado foi .96 indicando uma elevada consistência interna dos itens tal como verificado na versão original que foi de .88. Deste modo, a Escala da Intensidade da Fadiga apresenta boas qualidades psicométricas para ser utilizada como medida de avaliação da percepção da fadiga na população portuguesa de doentes com Lúpus Eritematoso Sistémico. Relativamente à validade de constructo, os resultados revelam que quanto mais intensa a fadiga percepcionada pelos doentes com LES, pior a qualidade de vida em todos os domínios (físico, psicológico, relações sociais e meio ambiente) e maior a sintomatologia depressiva e ansiosa apresentada. Palavras-chave: Fadiga Intensa, Lúpus Eritematoso Sistémico, Morbilidade Psicológica, Qualidade de Vida. _________________________________________________________________________________________________________________________________ SEVERE FATIGUE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A STUDY ON THE PSYCHOMETRIC PROPERTIES OF THE SEVERITY FATIGUE SCALE ABSTRACT:The main purpose of this study was the adaptation of the Fatigue Severity Scale (Krupp et al., 1989), which was designed to assess the perception of fatigue levels in patients with Systemic Lupus Erythematosus (SLE). Using a sample of 104 patients with SLE, the results showed that the Fatigue Severity Scale had a fidelity coefficient of .96, which indicates a high internal consistency of the items, like the original version (.88). The factor analysis showed the items, in the adapted version, to be organized in one factor only, as it happens in the original version. Thus, the Fatigue Severity Scale has good psychometric qualities that allow its use as an assessment tool in the evaluation the perception of fatigue in the Portuguese population of patients with Systemic Lupus Erythematosus. In terms of construct validity results showed, in patients with SLE, higher perceived fatigue to be associated with low quality of life in every domain (physical, psychological, social relationships and environment) and more depressive and anxiety symptoms.
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