Introduction:Acute generalized exanthematous pustulosis is characterized by small, sterile, non-follicular, and sudden-onset pustular reactions on an erythematous surface. It typically involves intertriginous regions and the trunk and is usually accompanied by itching and a feeling of pain in the lesion areas. Often pharmacological treatments and frequent viral eruptions, including enterovirus, coxsackie, Epstein-Barr virus, and hepatitis B, play a role in the etiology of the disease. Case report: Here, we present the case of acute generalized exanthematous pustulosis in a 17-year-old young woman triggered by the 1 st dose of COVID19 mRNA BioNTech vaccine. Conclusions: We are reporting a rare case of vaccine-related acute generalized exanthematous pustulosis, associated with a COVID-19 vaccination.