No abstract

No abstract

Three iminophosphine ligands having soft phosphorus and hard nitrogen atoms and their Pd(II) complexes were synthesized and characterized using 1H NMR, 13C NMR, 31P NMR and Fourier transform infrared spectroscopic techniques. Also, electrochemical properties of the iminophosphines and their Pd(II) complexes were investigated in acetonitrile–tetrabutylammonium perchlorate solution with cyclic and square wave voltammetry techniques. All Pd(II) complexes were evaluated as catalysts for carbonylative cross‐coupling reactions of aryl iodides with phenylboronic acid. The Suzuki carbonylation of aryl iodides at 80 °C under balloon pressure of carbon monoxide in the presence of K2CO3 as a base was examined, and good to high conversions and excellent selectivities were obtained.

PdCl 2 (HL 1 -κS) 2 ] and [PdCl 2 (HL 2 -κS) 2 ] complexes were formed from neutral monodentate modes of HL 1 and HL 2 ligands, which are coordinated to the palladium(II) center, respectively. [Pd(L 1 -κ 2 S,O) 2 ] and [Pd(L 2 -κ 2 S,O) 2 ] complexes were obtained by recrystallization of corresponding [PdCl 2 (HL 1 -κS) 2 ] and [PdCl 2 (HL 2 -κS) 2 ] complexes as anionic bidentate coordination modes. All palladium(II) complexes were characterized by elemental analysis, FT-IR, and

DNA has become the target of metal complexes in cancer drug discovery. Due to the side effects of widely known cisplatin and its derivative compounds, alternative metal-based drug discovery studies are still ongoing. In this study, the DNA-binding ability of Pd(II) and Pt(II) complexes of four phosphorus Schiff base ligands and four hydrazonoic-phosphines are investigated by using in silico analyses. Phosphorus Schiff base-Pd(II) complexes encoded as B1 and B2 with the best DNA-binding potential are synthesized and characterized. The DNA-binding potentials of these two new Pd(II) complexes are also investigated experimentally, and their antitumor properties are demonstrated in vitro in A549, MCF7, HuH7, and HCT116 cancer cells. The mechanisms of these metal complexes that kill the cells mentioned above in different activities are elucidated by flow cytometry apoptosis analysis and colony formation analysis The in silico binding energies of these two new palladium complexes ΔG (B1): −4.51 and ΔG (B2): −6.04 kcal/mol, and their experimental DNA-binding constants were found as Kb (B1): 4.24 × 105, Kb (B2): 4.98 × 105). The new complexes, which show different antitumor effects in different cells, are the least effective in HuH7 liver cells, while they showed the best antitumor properties in HCT116 colon cancer cells.