Background and Aims Caregivers are needed for cirrhotic patients as there is progressive decline in cognition and self‐care. We intend to study the quality of life (QOL), psychosocial burden and prevalence of mental health disorders among caregivers. Methods Cross‐sectional study where caregivers, defined as person who takes responsibility of providing care to patient, of cirrhotic patients were included. Short form 36 health survey (SF‐36) to assess QOL, Zarit Burdern Index12 (ZBI) for caregiver burden (CB). Patient Health Questionnaire (PHQ) identified depression and Generalized Anxiety Disorder (GAD‐7) questionnaires, anxiety. Results Of 132 caregivers, mean age of caregiver was 41.2 ± 10.3 years, with female preponderance. Mean MELD was 21.4 ± 7, majority belonged to CHILD C. Comparing the SF36 score of caregivers to normal population showed lower level of QOL for caregivers. Mean ZBI score – 14 ± 5.8. Mean GAD score – 8.1 ± 5.1, 54 (41%) had anxiety. Mean PHQ score – 7.8 ± 5.2, 45 (34%) had depression. Regression analysis Alcoholic cirrhosis, history of hepatic encephalopathy (HE), Anxiety, Depression and recidivism predicted CB. Treatment costs (ODDS‐1.15), alcoholic cirrhosis (ODDS –8.9), history of HE (ODDS‐7.5) and caregiver duration (ODDS‐0.25) predicted anxiety. Treatment costs (ODDS‐1.5), caregiver age (ODDS‐0.87), spouse as caregiver (ODDS‐10.9) and higher education (ODDS‐0.79) predicted depression. Conclusions Caregivers of cirrhotic patients have high prevalence of CB with low QOL and high incidence of anxiety and depression, compared with the general population. Alcoholism in patients precipitates while higher education helps cope up with these disorders.

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