This chapter provides an overview of the role of interventional pain management to reduce patients’ pain levels, and improve their mobility, activity levels, sleep, and quality of life. The key principles to be considered before, during, and after a pain intervention are described. The role of fluoroscopy, ultrasound, and computed tomography guidance to perform interventions is outlined. The factors that play a role in increasing the likelihood of complications from pain interventions (radiation safety/health care professionals/equipment/patient-related) and considerations to implement in daily practice to prevent patient harm are discussed. Furthermore, the role of chemical neurolysis, radiofrequency denervation, and pulsed radiofrequency treatment in interventional pain medicine is described.