Das smartLAB ist ein Verbund aus akademischen und nicht‐akademischen Partnern mit dem Ziel eine realistische Vision des Labors der Zukunft zu entwickeln. Hierfür wird eine digitale und interaktive Laborumgebung geschaffen, die den Menschen im Laboralltag anleitet und unterstützt, nicht ersetzt. In diesem Artikel werden dabei die Gebiete Geräteansteuerung, Workflow‐Entwicklung, Dokumentation und Nutzerinteraktion beleuchtet sowie das Zusammenspiel dieser Bereiche. Außerdem wird die hardwareseitige Umsetzung dargestellt und wichtige Konzepte erläutert.

Symbol Name Other designations, notes Calb1 Calbindin D-28K, calbindin D28 Calb2 Calretinin, Calbindin2 CR Camk2a calcium/calmodulin-dependent protein kinase II alpha CamkII subunit alpha Canx Calnexin Cnx Creb1 cAMP responsive element binding protein 1 Dab2ip disabled homolog 2 (Drosophila) interacting protein Dgkz diacylglycerol kinase zeta Diap1 diaphanous homolog 1 Dia1 Dlg2 disks large homolog 2 PSD-93, Psd93, Chapsyn-110 Dlg4 disks large homolog 4 PSD-95, Psd95 Eea1 early endosome antigen 1 Egf Epidermal growth factor Gad1 glutamic acid decarboxylase 1 EP10, GAD25, GAD44, GAD67 Gad2 glutamic acid decarboxylase 2 GAD65 Golgb1 Giantin, golgi autoantigen, golgin subfamily b, macrogolgin 1 Gm6840 Grb2 growth factor receptor-bound protein 2 Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) GluR1, GluA1, GluRA Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) GluR2, GluA2, GluR-B, Glur-Diese Studie enthält die ersten Beweise für eine spezifische neuronale Funktion von Rasgrp1. Sie zeigt, dass Rasgrp1 selektiv die postsynaptische Sensitivität an glutamatergen Synapsen reguliert. Diese Studie zeigt, dass die selektive Veränderung der Regulation von Ras eine hilfreiche Methode ist, um die vielfältigen Effekte der Ras Signaltransduktion in Neuronen verstehen zu können.represent the postsynapse. Upon binding of Glutamate, the receptors open and allow Sodium to enter the cell. Upon this influx of cations, the cell depolarizes locally. This electrical signal propagates as the depolarization passively spreads through the dendrites. Spine shape, dendrite caliber and branching influence signal propagation as it travels to the soma. In the soma, final integration of all incoming signals takes place. If the resulting depolarization passes a certain threshold, a new action potential is generated in an all-or-none fashion.Postsynaptic spines, dendrites, the soma, the axon and presynaptic boutons represent highly specialized compartments that are part of the complex morphology of neurons. In fact, without knowledge of ion channels or biophysical properties of the II.3. Controversies in the Research of Neuronal Ras SignalingSince publication of the findings described above, research on neuronal Ras signaling has led to many controversies. In this regard, one experimental system in particular appears to have given rise to most of the controversies in the field.Extensive research on Ras signaling is conducted using activated mutants of Ras proteins. The activated mutated protein is able to bind GTP, but unable to hydrolyze it to GDP and therefore remains in a constitutively active state (Karnoub and Weinberg, 2008). The corresponding frequently used Glycine to Valine mutation at amino acid (aa) position 12 (G12V) is normally found in oncogenic Hras.The first electrophysiological study linking Ras signaling to LTP was in fact a KO study on Rasgrf1 (also known as cdc25NEF, RasGRF, GRF1), a Ras activator.The protein had been identified and cloned by three independent groups (Cen et al., 1992;Martegani et al., 1992;Shou et al....

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