Intravascular (IV) administration of contrast media (CM) is commonly utilized to enhance the capabilities of imaging modalities commonplace in both diagnostic and therapeutic interventions. There are numerous iatrogenic reactions associated with CM administration that have been described in literature, 1 broadly categorized as allergic and nonallergic. Postcontrast acute kidney injury (PC-AKI) is a subset of nonallergic CM reactions and is especially important in patients with an underlying medical condition such as chronic kidney disease (CKD). This may be exacerbated by IV administration of CM during long interventional procedures such as angiography. In this article, a case of PC-AKI is presented followed by a discussion of the topic. In addition, guidelines for prevention and treatment of PC-AKI are presented.