Purpose: Nursing is a profession who belong to care of community, a universal perception. Nurses job criteria belongs to many distractions and obstacles in performing their job. Interruption is considered to be part of workplace. The nursing profession responsibility and reliability are of high concerns because it deals with the life of human beings. Interruption at workplace compromises the patient safety. The study sought to explore the knowledge, attitude, and practices regarding nursing interruption among nurses. Methodology: Descriptive cross-sectional study design used. Questionnaire a tool used to collect data from tertiary care hospital (n=115). The tool contains a dimension of knowledge attitude and practice scoring of questionnaires as knowledge 50 score, attitude 45 and practice 28, respectively number questions each domains knowledge 10, attitude 9 and practice 7. Results: The KAP regarding interruption among Pakistani nurses score range (26-123). The means of knowledge attitude and practices respectively 31.2957 ± 7.21229, 33.1478 ± 5.68507, 19.5826 ± 3.86841. the collective mean and standard deviation of knowledge attitude and practice 84.0261 ± 16.76577. correlation statistically significant in KAP (p<0.05). Coefficient of correlation knowledge enhance practices. The combined KAP of respondents was 69%.  Unique contribution to theory, practice and policy: Knowledge attitude and practice prime parameters of confirming the quality of understanding and performance. Study concluded that nurses have moderate level of knowledge attitude and practice 69%. The knowledge and attitude positive coefficient correlation, enhance each other. Gender, increased academic qualification, attention of leader and experience correlation with KAP. Experience and age group 10-15 years possess a high degree of knowledge attitude and practice. There is a need for interruption management training moreover requiring leader attention. Basic understating about interruption on a clinical place not considerably efficient. The dependent variable causes a 20% variance in the criterion variable.