The offshore oil and gas industry is experiencing increasing water cuts as the reservoirs mature. The increase in produced water stresses the currently deployed deoiling technologies, resulting in more oil in the discharged water. Deploying membrane filtration to reduce the hydrocarbon concentration inherits additional complications related to fouling of the membranes: A process where the accumulation of material within and on the membrane surface adds additional flow resistance. This paper reviews and analyses the fouling detection, removal, prevention, dynamical and static modeling, with emphasis on how the membrane process can be manipulated from a process control perspective. The majority of the models rely on static descriptions or are limited to a narrow range of operating conditions which limits the usability of the models. This paper concludes that although the membrane filtration has been successfully applied and matured in many other industrial areas, challenges regarding cost-effective mitigation of fouling in the offshore deoiling applications, still exist. Fouling-based modeling combined with online parameter identification could potentially expand the operating range of the models and facilitate advanced control design to address transient performance and scheduling of fouling removal methods, resulting in cost-effective operation of membrane filtration systems. With the benefits of membrane filtration, it is predicted that membrane technology will be incorporated in produced water treatment, if the zero-discharge policies are enforced globally.

Planar silicon chips with 1-2-microm etched holes (average resistance: 2.04 +/- 0.02 MOmega in physiological buffer, n = 274) have been developed for patch-clamp recordings of whole-cell currents from cells in suspension. An automated 16-channel parallel screening system, QPatch 16, has been developed using this technology. A single-channel prototype of the QPatch system was used for validation of the patch-clamp chip technology. We present here data on the quality of patch-clamp recordings and from actual drug screening studies of human potassium channels expressed in cultured cell lines. Using Chinese hamster ovary (CHO) and human embryonic kidney cells (HEK), gigaseals of 4.1 +/- 0.4 GOmega (n = 146) and high-quality whole-cell current recordings were obtained from hERG and KCNQ4 potassium channels. Success rates for gigaseal recordings varied from 40 to 95%, and 67% of the whole-cell configurations lasted for >20 min. Cells were maintained in suspension up to 4 h in a cell storage facility that is integrated in the QPatch 16. No decline in patchability was observed during this time course. A series of screens was conducted with known inhibitors of the hERG and KCNQ4 potassium channels. Dose-response relationship characterizations of verapamil and rBeKm-1 blockage of hERG currents provided IC(50) values similar to values reported in the literature.

A lab-on-a-chip device that enables positioning of single or small ensembles of cells on an aperture in close proximity to a mercaptopropionic acid (MPA) modified sensing electrode has been developed and characterized. The microchip was used for the detection of Ca(2+)-dependent quantal catecholamine exocytosis from single as well as small assemblies of rat pheochromocytoma (PC12) cells. The frequency of events increased considerably upon depolarization of the PC12 cell membrane using a high extracelluar concentration of potassium. The number of recorded events could be correlated with the number of cells immobilized on the electrode. Quantal characteristics, such as the number of released molecules per recorded event, are equivalent to data obtained using conventional carbon fiber microelectrodes. The detection sensitivity of the device allows for the detection of less than 10 000 dopamine molecules in a quantal release. The distribution of peak rise-time and full width at half maximum was constant during measurement periods of several minutes demonstrating the stability of the MPA modified surface.

Multi-phase flow meters are of huge importance to the offshore oil and gas industry. Unreliable measurements can lead to many disadvantages and even wrong decision-making. It is especially important for mature reservoirs as the gas volume fraction and water cut is increasing during the lifetime of a well. Hence, it is essential to accurately monitor the multi-phase flow of oil, water and gas inside the transportation pipelines. The objective of this review paper is to present the current trends and technologies within multi-phase flow measurements and to introduce the most promising methods based on parameters such as accuracy, footprint, safety, maintenance and calibration. Typical meters, such as tomography, gamma densitometry and virtual flow meters are described and compared based on their performance with respect to multi-phase flow measurements. Both experimental prototypes and commercial solutions are presented and evaluated. For a non-intrusive, non-invasive and inexpensive meter solution, this review paper predicts a progress for virtual flow meters in the near future. The application of multi-phase flows meters are expected to further expand in the future as fields are maturing, thus, efficient utilization of existing fields are in focus, to decide if a field is still financially profitable.

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