No abstract

Aim-To analyse whether the mean nuclear area of the 10 largest nuclei (MNA-10), the mitotic activity index (MAI), and Ki-67 immunoquantitative features have additional value to discriminate diVerent grades of T A,1 transitional cell carcinoma (TCC) of the urinary bladder. Materials/Methods-One hundred and fifty of 200 consecutive cases (75%) showing interobserver agreement on duplicate blind grade assessment by independent pathologists were studied. Using random numbers, the 150 cases were divided into sets for learning (n = 75) and testing (n = 75). Single and multivariate analyses were applied to discriminate the diVerent grades in the learning set. The multivariate classifier developed in this way was evaluated in the test set (n = 75). Results-With