No abstract

No abstract

The dynamics of an interface plasma-plasma self-structured as a double anodic layer using the fractal space-time theory is established. So, for the fractal dimension D = 2, the Schrödinger "fluid" is obtained as an irrotational movement of a Navier-Stokes fluid with an imaginary viscosity coefficient. In the deterministic case, the anodic double layer is described by a set of diffusion-reaction equations, a situation in which the equal diffusion curves are of the Koch-type and the self-structuring is given by means of the coherence of the electron-ion pairs. In the nondeterministic case, the anodic double layer is described by a set of time-dependent Schrödinger-type equations and the self-structuring is given by means of the negative differential resistance and the pulsation-potential linear dependence. Through the spontaneous symmetry breaking the Langmuir's relations, the distributions of the potential field and charge densities have been obtained. The model was verified by means of our experimental data too.

Topical liposomal drug formulations containing AS1411-aptamer conjugated liposomes were designed to deliver in a sustained way the 5-fluorouracil to the tumor site but also to increase the compliance of patients with basal cell carcinoma. The 5-fluorouracil penetrability efficiency through the Strat-M membrane and the skin irritation potential of the obtained topical liposomal formulations were evaluated in vitro and the Korsmeyer Peppas equation was considered as the most appropriate to model the drug release. Additionally, the efficiency of cytostatic activity for targeted antitumor therapy and the hemolytic capacity were performed in vitro. The obtained results showed that the optimal liposomal formulation is a crosslinked gel based on sodium alginate and hyaluronic acid containing AS1411-aptamer conjugated liposomes loaded with 5-fluorouracil, which appeared to have favorable biosafety effects and may be used as a new therapeutic approach for the topical treatment of basal cell carcinoma.

The anodic double layer is studied by electrical methods. Irradiating this layer with an optical electromagnetic radiation, resulted in current intensity oscillations and also an increase in their amplitude. A theoretical model is described on the basis of a nonlinear diffusion equation, and both double layer diameter and characteristic oscillation time were calculated. Theoretical results are in agreement with experimental results.