The various insufficiencies or even diseases generated by the intoxication with the various substances, affect the quality of life -both of the intoxicated person and of those in the social environment in which he lives and works. The present article aims to analyse a series of perspectives regarding the role and importance of studying chemistry in the professional training of future doctors, especially residents in the field of forensic medicine.

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Craniocerebral trauma is the most common cause of death and post-traumatic disability in people under 45 years of age. In Romania, the annual incidence shows, that for every 100,000 inhabitants, there are 300 cases of craniocerebral trauma that require specialized medical assistance. Craniocerebral traumas are the most common types of traumas encountered in current forensic practice. Research on the mechanisms of injury, the timing of head trauma and the establishment of causes of death remain relevant. Establishing the traumatic moment implies both the distinction between pre-mortem and post-mortem injuries but also considerations regarding the post-traumatic survival interval. Regarding the elucidation of the moment of occurrence of the craniocerebral trauma from the forensic point of view, a satisfactory result has not been reached so far. The classic hypothesis regarding the development of traumatic brain injuries shows that they are the result of primary traumatic injuries due to cell necrosis combined with the inflammatory brain response that causes secondary brain injuries. It was considered that post-traumatic neuronal losses are strictly due to necrosis and inflammation, and cellular apoptosis being a physiological process, does not play a role in this process. Due to recent experimental data, brain cell apoptosis has begun to be reevaluated. The pathophysiology of traumatic brain injury is far from being fully understood, with the idea that apoptosis would play an even more important role than originally thought. Specifically, damaged brain cells release neuromodulatory substances that can lead to late-onset neuronal damage long after necrotic and inflammatory brain phenomena have ceased to act. These neuronal cell losses are responsible for the development of various neurological deficits and post-traumatic sequelae.

Safety measures are both a way of isolating the person who committed a criminal offence from society, with the purpose of protecting citizens, and at the same time a form of protection for the perpetrator, against whom the most appropriate measures are taken -from from the point of view of the the criminal justice system -in consideration of their particular situation. Among the categories of perpetrators to whom safety measures are addressed, those with mental retardation represent a specific category in that, unlike other psychically ill offenders, their degree of perceiving the consequences of their actions and their own guilt is extremely low, and sometimes it is even impossible for them to understand the significance of their own deeds. The present article aims to highlight the specific elements of safety measures imposed on mentally retarded criminal offenders from a theoretical perspective, analyzing the concepts of deviance and delinquency by correspondence with irresponsibility.

Cerebral oedema in diabetic ketoacidosis (CODKA) is a controversial subject both in medical and forensic practice as well as in the specialized literature, in the light of the non-homogeneous theories regarding the pathophysiological mechanisms. It would seem that the ground of CEDKA would be a combination/fusion of processes that affect both metabolic changes in diabetic ketoacidosis (DKA) and aggressive therapy to combat DKA. This article wants to underline the importance of knowing and deepening the pathophysiological mechanism that leads to the installation of cerebral oedema (CO) in DKA, focusing on the potential of the thanatogenerator mechanism.