Introduction: Brugada phenocopies are recently introduced as clinical entities with electrocardiographic patterns identical to true congenital Brugada syndrome in individuals, who are asymptomatic and have no other clinical criteria. One of the largest methanol poisoning outbreaks occurred in Iran during March and April 2020. This study aimed to investigate the relationship between Brugada Phenocopy with laboratory data and demographic factors and determine its association with mortality rate in methanol toxicity patients. Method and results: Demographic data such as age, gender, medical history, Glasgow coma scale score, laboratory data, and electrocardiographic data were obtained from 356 patients, who were diagnosed with methanol poisoning and were hospitalized in Faghihi and Namazi Hospitals in Shiraz, southern Iran, during March and April 2020. The follow-up data was gathered to examine the development of any complications or death. A total of 20 (5.6%) patients were admitted with a diagnosis of methanol toxicity and concurrent Brugada-like ECG patterns. Mortality rate, Glasgow Coma Scale Score <3, and blood sugar were significantly higher in the Brugada phenocopies; however, PH, O2 saturation, and calcium were lower among Brugada phenocopies in comparison to methanol toxicity patients with no Brugada pattern (P<0.05). Conclusion: According to the findings of this study, some recognizable ECG patterns and laboratory data may be used as novel prognostic factors of morbidity and mortality. Electrocardiography machines are widely available, and electrocardiograms can easily be obtained and interpreted. This may provide the grounds for caregivers to predict and prevent the incoming death and react more properly and timely.

Objective. J point and coved ST elevation in right precordial leads (not produced by coronary artery disease) are still a matter of challenge, especially when resembling Brugada patients. This clinical entity, among asymptomatic individuals with no family history of sudden cardiac death, would be reported in some severely ill patients before ventricular fibrillation. This study investigated the relationship between the electrocardiograms with demographic and laboratory data and also analyzed their association with mortality rate among patients with methanol poisoning. Methods. The sample consisted of 356 patients who were hospitalized with a diagnosis of methanol poisoning in Faghihi and Namazi Hospitals in Shiraz, Southern Iran, in March and April 2020. In this period, a major outbreak of methanol poisoning had occurred in this area. Furthermore, the study used the data on any recorded complications or mortality during hospital course. Results. The ECG (BrP) was observed in a total of 20 (5.6%) patients. Its presence was associated with increased mortality, Glasgow coma scale score <3, and blood sugar levels and was inversely associated with PH, O2 saturation, and calcium levels ( P < 0.05 ). Conclusions. This study found that certain ECG patterns and laboratory data can be used as prognostic factors of morbidity and mortality in patients with methanol intoxication. Electrocardiography machines are widely available tools, which can be easily used for risk stratification based on the presence of Brugada approximating electrocardiograms among patients with methanol intoxication.

Mitral Annular Calcification (MAC) could even be a chronic, degenerative process of the fibrous support structure of the mitral valve [1,2]. MAC is usually visualized on echocardiography as an echo-dense shelf-like structure with an irregular, lumpy appearance involving the mitral valve annulus, with associated acoustic shadowing. within the Cardiovascular Health Study [3], MAC was quantified as mild (focal, limited increase in echodensity of the mitral annulus), moderate (marked echodensity involving one third to a minimum of 1 half the ring circumference), or severe (marked echodensity involving quite half the ring, or with intrusion into the left ventricular [LV] inflow tract).