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Background: Diuretics increase urine flow and sodium excretion are used to maintain the volume and composition of body fluids in a variety of clinical situations Objectives:  To evaluate the diuretic activity of alcoholic (AERMI) extract of roots of Mangifera indica in albino rats.  Methods: 5 groups of Albino rats were used to evaluate the diuretic activity by using metabolic cages. The group I serves as normal control received vehicle, the group II received Furosemide (10 mg/Kg, p.o) ; other groups III, IV, V were treated with low, medium, and high doses of AERMI and immediately after extract treatment all the rats were hydrated with saline (15 ml/kg) and placed in metabolic cages. Total volume of urine collected was measured at the end of 5 h. Concentration of Sodium, Potassium, Chloride in the urine were estimated. Results: Compared to control group the AERMI at different dose levels (100,200 and 400 mg/kg) has significantly increased the urine volume and also enhanced the elimination of Sodium, Potassium and Chloride. Conclusion: Single dose of AERMI as 100, 200 and 400 mg/Kg and Frusemide have increased the urine output along with an increase in concentration of Sodium, Potassium, and Chloride.

Background: Adverse drug reactions (ADR) are global problem causing morbidity and mortality. Good pharmacovigilance (PV) programme can address this problem. Under reporting of ADR is one of the obstacles for good PV. In order to achieve this, health professionals need to have enough Knowledge, attitude and practice (KAP) of ADR`s. The present study was conducted to assess KAP about PV among post graduate (PG) students.Methods: A self administered questionnaire validated by Lynn M consisting of 22 questions covering knowledge, attitude & practice about PV was distributed among PG students of clinical departments of MIMS College. Answering of the questionnaires was supervised directly. Filled questionnaires were analyzed by using Microsoft Excel spread sheet.Results: Evaluation showed an average of 52.3% correct and 47.7% incorrect knowledge about ADR`s and PV.50% students are not sure regarding occurrence of ADR.90% students are not been trained upon reporting of ADR`s. Our study found out that PG students have better attitude towards PV, but have improper knowledge & less awareness about PV. We also found lack of practice among the students.Conclusions: Imparting knowledge and awareness of PV among the PG students by means of continuous educational intervention can create better practice among PG students.

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