Objective: To evaluate the allele and genotype frequencies of the P561T and C422F polymorphic sites of the growth hormone receptor (GHR) gene and the relationship between mandibular prognathism (MP) and these two single-nucleotide polymorphisms (SNPs). Materials and Methods: A total of 99 subjects with severe skeletal Class III MP who planned to undergo orthognathic surgery and 99 subjects with Class I occlusion were examined in this study to evaluate the relationship between MP and two SNPs in exon 10 of the GHR gene. GHR was chosen as a candidate gene because growth hormone plays an important role in cartilage growth. A blood sample was used to extract genomic DNA, and the polymerase chain reaction-restriction fragment length polymorphism method was used to determine genotypes of P561T and C422F. The Minitab 14.0 packet program was used to perform statistical analysis. Results: Allele frequencies of the C422F and P561T variants were determined. Because of the low allele frequency of the control group, statistical analysis could not be performed to test the difference between MP and control groups. Therefore, the data were combined to determine the association between the P561T polymorphism and craniofacial measurements. Effective mandibular length (condylion-gnathion) and lower face height (anterior nasal spina-menton) were associated with the P561T variant. Conclusion: This finding supports that the GHR might be a candidate gene for mandibular morphogenesis in this population. (Angle Orthod. 2014;84:803-809.)

ObjectiveTo evaluate the long-term effects of self-ligating brackets (SLBs) on transverse dimensions of arches and skeletal and soft tissues and to quantitatively evaluate the treatment outcome after non-extraction treatment with SLBs.MethodsThe sample consisted of 24 (18 female and six male) subjects, with a mean age of 14.23 ± 2.19 years, who received treatment with the Damon®3 appliances. Complete records including cephalometric radiographs and plaster models were obtained before treatment (T1), immediately after treatment (T2), six months after treatment (T3), and two years (T4) after treatment. Digital study models were generated. Twenty lateral cephalometric, six frontal cephalometric, and eight dental cast measurements were examined. The Peer Assessment Rating index was used to measure the treatment outcome. The Wilcoxon test was applied for statistical analysis of the changes.ResultsThere were significant increases in all transverse dental cast measurements with active treatment. There was some significant relapse in the long term, particularly in maxillary width (p < 0.05). Statistically significant increases were found in nasal (p < 0.001), maxillary base, upper molar, lower intercanine, and antigonial (p < 0.05) widths in T1-T2. Lower incisors were proclined and protruded in T1-T2.ConclusionsSLBs correct crowding by mechanisms involving incisor proclination and protrusion and expansion of the dental arches, without induction of clinically significant changes in hard and soft tissues of the face.

Kronik böbrek yetmezliği (KBY) olan çocuklarda azalmış ve değişmiş tat duyusu, azalmış iştah, azalmış oral alım, kusma, enfeksiyonlar, hastaneye yatış ve psikososyal sorunlar gibi nedenlerden dolayı yetersiz beslenme sık görülmektedir. Buna ek olarak sıvı-elektrolit bozukluğu, metabolik asidoz, renal osteodistrofi, kronik anemi ve azalmış insülin benzeri büyüme faktörü 1 (IGF-1) büyüme gelişme geriliğini şiddetlendirmekte, genellikle büyümede duraklamaya neden olmaktadır. Bu makalede KBY tanısı ile izlenen olgunun tedavisinde tıbbi beslenme tedavisinin yönetimi ve önemi tartışılacaktır.

Carbohydrate counting provides better glycemic control and flexibility than other food planning methods. Consistent adherence to such a complex method is difficult, especially for youth. However, studies that determine adherence to this method and whether it alters metabolic control are limited. The aim of the current study was to determine adherence to this method and investigate its effect on metabolic control, anthropometric measurements, insulin dose, and energy intake. Methods: In this prospective cross-sectional study, 53 children and adolescents with type 1 diabetes mellitus aged 2 to18 years and receiving intensive insulin therapy were trained and followed for 6 months. Demographics, anthropometrics, insulin requirements, hemoglobin A1c (HbA1c), fasting lipids, and food records at baseline and study conclusion were evaluated. At the end of the study patients were divided into adherer and nonadherer groups according to carbohydrate estimate deviations from standardized daily sample menus and calculations for accurate insulin doses. More than 10-g variation in daily consumed carbohydrate amount or failure to decide bolus insulin dose was defined as a nonadherer. Results: The mean HbA1c, low-density lipoprotein cholesterol, and body mass index standard deviation score changed after the carbohydrate counting training while the mean HbA1c between groups was significant (P<0.05). Total daily insulin doses increased, and the mean high-density lipoprotein cholesterol levels decreased in both groups. There were significant correlations between HbA1c and carbohydrate deviation scores as well as HbA1c and caregiver's education level. Conclusion: Since adherence to carbohydrate counting may affect metabolic control, health professionals should evaluate and monitor carbohydrate counting skills of caregivers and patients in order to improve efficiency.

Background: Concerns about physical appearance and other body characteristics are central to adolescents’ sense of self-worth and have the potential to affect adolescents’ nutrition habits and overall well-being. Aim: This study was planned and conducted to determine the relationship between nutritional habits, social anxiety levels, and physical activity levels of students in the pubertal period. Materials and Methods: 300 students were enrolled in this descriptive cross-sectional study between the ages of 14-18 who lived in Ankara, between October 2017 and February 2018. The Mediterranean Diet Quality Index (KIDMED) was used to determine healthy eating habits, the International Physical Activity Form (IPAQ) to determine physical activity status, and the Social Physique Anxiety Inventory (SPAS) to determine social anxiety levels. Results: 232 girls and 68 boys participated in the study. There was no statistically significant difference between KIDMED, IPAQ, or SPAS by sex (p> 0.05). Students who stated that they eat a healthy diet had higher KIDMED scores and lower SPAS scores than those who had an unhealthy diet (p<0.05). Physical activity levels were similar in both groups (p>0.05). There was a positive correlation between KIDMED and IPAQ results, and negative correlations between KIDMED and SPAS and Body Mass Index for age (p<0.05). There was a negative but insignificant correlation between IPAQ and SPAS scores (p>0.05). Conclusion: Adherence to the Mediterranean diet and higher physical activity levels may protect adolescents from obesity, obesity-related comorbidities, and high social anxiety levels.