Orthodontic treatment is the reorganization of skeletal and/or dental tissues. Prolonged treatment duration is one of the main concerns of patients undergoing with fixed orthodontics. This extended orthodontic treatment in such particular cases has several drawbacks to the patients such as increased predisposition to root resorption, dental caries and gingival recession, etc. Consequently, researchers introduced few methods to accelerate the velocity of the tooth movement without any drawbacks. These kind of methods used in orthodontics were popular as accelerated orthodontics. Accelerated orthodontics could be possible by mechanical stimulation or device assisted therapy, surgical therapy and by the use of pharmacological agents. The purpose of the present manuscript was to describe and evaluate the methods used in accelerated orthodontics.Keywords: Accelerated orthodontics; Conventional orthodontic treatment; Corticotomy; Tooth movement IntroductionThe movement of tooth orthodontically happens under mechanical forces depends upon the alteration of the tissues surrounding its radicular part. These mechanical force creates a response in cellular component of surrounding periodontal ligament (PDL), that creates resorption in bone on pressure side and deposition of bone on the either side (tension side) [1]. This is an inflammatory process and the rate limiting factor for tooth movement is bone resorption at the bone and periodontal ligament interface [2]. Orthodontic movement can be controlled by the size of the applied force and the biological responses from the periodontal ligament [3]. This orthodontic force would cause inflammation around the periodontal ligament due to changes in blood flow, leading to the secretion of different inflammatory mediators like colony-stimulating factors, cytokines, growth factor, arachidonic acid metabolites and neurotransmitters. As a result of these secretions, remodelling of the bone occurs [4,5].Macrophage colony stimulating factor (M-CSF), Receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) by osteoblasts play key roles in tooth movement has been showed in Figure 1. RANKL binds to its receptor, RANK (Receptor activator of nuclear factor kappa B), on the surface of osteoclastic cells at developmental stage. The RANKL/RANK binding is very critical for the function, differentiation, and survival of osteoclasts. Fixed orthodontics could last for 24 to 36 months which further poses the risk of complications associated with the treatment such as external root resorption, periodontal problems and patient compliance. Orthodontists are persistently motivated towards developing potential strategies to enhance the rate of orthodontic tooth movement [6][7][8] AOTM has been preferred for its numerous prospective benefits like shorter treatment duration, differential tooth movement, enhanced envelope of tooth movement, improved post treatment stability and reduced side effects [9]. Attempts to AOTM can be dated back to the 1890s, where Cunningh...