For the therapeutic management of various types of cancer, paclitaxel (PTX) is commonly used for chemotherapy. Peripheral neuropathy, neuropathic pain, behavioral changes and emotional depression are all side effects of PTX therapy, but their effect on food consumption and body weight gain in adult patient have not been well reported so far. Therefore, present study aimed to evaluate the impact of PTX on food consumption and body weight gain in adult female Wistar rats. In this study, selected equivalent therapeutic doses of PTX (1.6 and 3.2 mg/kg bw) were administered intermittently for six weeks (once a week) intravenously in tail vein via catheter. During experiment, food consumption and body weight of PTX exposed and control rats were recorded. During six weeks of intermittent exposure, our results revealed dose-dependent substantial reduction in food consumption and body weight except first week of PTX exposure in adult Wistar female rats. The effect of equivalent therapeutic doses of PTX was found to be associated with feeding pattern (anorexia) and body weight loss (body mass index) involving multifactorial regulatory mechanisms for controlling the food consumption and body weight changes.

This paper investigated application of web 2.0 to private university libraries of northern part ofNigeria based on Mannes theory which emphasizes on changing scenario of librarianship withthe presence of the web, (10) private university libraries website which are of quality and ICTcompliant by Nigerian standard were surveyed to identify the presence of web 2.0 toolapplication and purpose for application. Only (4) 40% had applied web 2.0 tool, the mostapplied web tool was WebOPAC followed by social networking sites, and (1) private universitylibrary had applied RSS, no other web tool have been applied. Even with the web 2.0 boom andadvantages web 2.0 provides to library professional for interaction, the application is still verymuch low in Nigerian libraries. The study recommends Training of library professionals,provision of ICT infrastructure, restructuring of library school curriculum.

Paclitaxel (PTX) is a microtubule inhibitor commonly used as a potent chemotherapeutic agent for treatment of a variety of cancers including breast cancer. PTX is causing several serious side effects during and after chemotherapy related to metabolic and renal dysfunctions. Clinical and non-clinical studies on PTX exposure and histopathological changes in liver and kidney are limited; therefore present study was designed to evaluate hepatotoxicity and nephrotoxicity of PTX in adult female rats. In this regimen, equivalent therapeutic doses of PTX (1.6 and 3.2 mg/kg BW) were intravenously administered weekly for six weeks. After six weeks of exposure, liver and kidney of PTX exposed and control rats were extirpated, fixed in 10% neutral buffered formalin for paraffin sectioning. As per protocol, sections of liver and kidney were cut at 8 µm and finally stained with Haematoxylin and Eosin. Our results demonstrated that intermittent exposure to PTX for six weeks (once per week) induced substantive histopathological changes in liver (hepatocyte derangement, blood clotting, and CV dilatation) and kidney (glomerular atrophy, vascular congestion, dilation of distal tubules) of female rats.