Background: The National Safety Goal recommendation for American hospitals, the Australian Commission on Safety and Quality in Health Care and The European Resuscitation Council Guidelines for Resuscitation recommend the use of a Medical Emergency Team (MET)-system to improve hospital safety and quality of care through preventing cardiac arrests and unplanned ICU admissions. However, there is little evidence of its effectiveness. Objective: To evaluate the effectiveness of educational interventions in improving MET nurses' performance. Methods: The systematic literature review was conducted in five multidisciplinary databases without any time constraint during the autumn 2016. The studies were selected and assessed by two researches independently. The analysis was conducted by following the principals of narrative synthesis. Results: Due to a lack of suitable studies only two studies were included in the review. They confirmed simulation team training to be effective and preferred method amongst MET team. Specific role assumption and tasks completion increased MET effectiveness. Conclusion: The effectiveness of MET educational interventions remains unclear due to the lack of published studies. There is a need for new innovative educational intervention studies to clarify, educate, evaluate and improve MET nurses' performance and their assigned tasks and roles. Keywords Medical Emergency Team (MET); Rapid Response Team (RRT); MET nurse; Education; Training Key Points: 1. Simulation provides opportunities for team training, and simulation is a recognized MET training tool. 2. The most effective educational interventions for MET are still questionable. As ICU nurses are frequent members in MET, their effective education can influence the whole team performance as well as the hospital safety and quality. 3. Randomized controlled trial studies are needed to evaluate the effectiveness of different kinds of simulation-based interventions as well as to compare them to other educations to determine the most effective education for the MET system. Highlights: • The effectiveness of education on MET nurses' performance remains unclear. • Simulation education is preferred method for MET. • Efficiency improves by assuming specific roles and performing role delineated tasks. • New educational intervention studies are needed to evaluate MET performance.