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<p>Selenium has been shown a wide range of pleiotropic effects, particularly the antioxidant and anti-inflammatory effects. However, there are limited cohort studies exploring the association between blood selenium concentrations and lung function in young adults.To explore the longitudinal association between blood selenium concentrations and lung function among young adults in China. A total of 1,800 participants were recruited from a Chinese undergraduate cohort in Shandong province, China during August 2019, and followed up in September 2020. Socioeconomic and demographic information were collected for each individual using standard questionnaires. Blood selenium was measured using inductively coupled plasma mass spectrometry at baseline. Linear mixed-effects models were used to explore the longitudinal association between blood selenium levels and lung function indicators of forced vital capacity (FVC, ml), forced expiratory volume in 1 second (FEV₁, ml) and peak expiratory flow (PEF, ml), followed by stratified analyses regarding sex, respiratory disease history, socioeconomic status and physical activities.The median level of blood selenium concentration among all participants was 120.9 (25^th: 107.5, 75^th: 137.5) ng/ml. In the longitudinal analysis, each 2-fold increase in blood selenium concentrations was significantly associated with 91.14ml (95%CI: 6.80, 175.48) increase in FEV₁ and 270.23ml increase (95%CI: 53.70, 486.75) in PEF, respectively. The beneficial associations were stronger for women, participants with respiratory disease, socioeconomic status advantage, and those who did not participate in physical activity. High levels of blood selenium concentrations were associated with improved lung function, especially airway obstruction function in young adults. The selenium concentration of 175ng/ml could possibly be the excess up-limit.</p>

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