Objective:The 309 T/G polymorphism of murine double minute 2 (MDM2) gene is associated with acute myeloid leukemia, but conflicting results have been reported. In this study, we performed a meta-analysis to estimate the association between MDM2 309 T/G polymorphism and acute myeloid leukemia risk.Methods: Electronic search of PubMed was conducted to select case-control studies that contain available genotype frequencies of the MDM2 309 T/G polymorphism. Pooled Odds Ratio (OR) with 95% Confidence Interval (CI) was used to assess the strength of the association.Results: Six case-control studies, which consist of 1121 cases and 3974 controls, were identified. After pooling all the eligible studies in the meta-analysis, we found that the MDM2 309 T/G polymorphism was significantly associated with risk of acute myeloid leukemia (Recessive model G/G versus T-carriers: OR=1.738, 95% CI: 1.424 -2.122, p= 0.000; additive model G versus T: OR = 1.298, 95% CI: 1.159-1.453, p= 0.000). Symmetrical funnel plot derived from Egger's test (P=0.970) and Begg's test (P=0.851) indicated the lack of publication bias.Discussion: This meta-analysis suggests that individuals with T/G or G/G genotype of MDM2 SNP309 were significantly associated with increased acute myeloid leukemia risk. To draw comprehensive and true conclusions, well-designed studies with large sample sizes and representing different ethnicities are required.

In today's era, with a variety of different factors, cancer has become a common disease in today's times; the cancer is very different according to the different types of organizations. As one of the most common malignant tumors, the incidence and mortality of liver cancer is relatively high. In this study, based on the current situation of the incidence and mortality of liver cancer, the importance and accuracy of serum tumor markers and CTC in the diagnosis of liver cancer were analyzed. The results show that serum tumor markers and CTC can improve the accuracy of diagnosis.