Ketogenic diets (KD) have become popular diet to lose weight. However, the effect of such diets on brain function has not yet been clarified. Thus, we aimed to study the effects of KD on the neurogenesis and apoptosis in the dentate gyrus by assessing the expression of Ki-67 and Caspase-3. Rats (n = 24) were divided into four groups: control (normal diet), ketogenic diet (KD), time-restricted diet (TRD), and the combination of high-fat and time-restricted diet (CD) groups. The expression of Ki-67 in the TRD and CD groups was higher compared to others (P < 0.05), whereas no such difference was observed in the KD group. The number of Capase-3-positive cells decreased significantly in the TRD group (P < 0.05), but such decrease was not observed in the CD group. These results indicate that, although KD could be effective in reducing the body weight, possible adverse effect in the brain cannot be ignored.
Reducing the incidence of stunting is one of the goals of the 2025 Global Nutrition Targets. The prevalence of stunting in children in Indonesia is still high over the last decade. Lack of knowledge on nutritional intake, maternal nutritional status factors, breastfeeding practices, complementary feeding practices, and exposure to infections as well as other factors including education, food system, health care, and sanitation are important determinants of child stunting in Indonesia. This community service activity is carried out with the aim of providing counseling about stunting to mothers and measuring the nutritional status of toddlers as an effort to prevent stunting. The activity was coordinated by students who are members of the Student Executive Board of the Faculty of Medicine, Sriwijaya University (FK Unsri) and Muhammadiyah University (FK UM), involving FK Unsri lecturers, in collaboration with staff at the Puskesmas Taman Bacaan Palembang. At the end of the activity, participants became more aware of the importance of measuring children's nutritional status and stunting prevention measures. There were 6 toddlers who were indicated to be malnourished and reported for management by the Puskesmas team so that they did not progress to stunting.
Indonesia is currently experiencing the second wave of the Covid-19 pandemic. The Coronavirus is currently spreading faster with a higher severity, causing an increase in Covid-19 cases in the UNSRI Medical Faculty. There were 73 students and 13 lecturers and/or educators who were confirmed to have Covid-19 as of July 14, 2021, who had been recorded since early July. The increase in the number of confirmed cases of Covid-19 in students and lecturers causes the teaching and learning process to be suboptimal. . In addition, the increasing number of Covid-19 in the community while access to hospitalization is reduced, causing many people to need to self-isolate at home, who need a consultation about their health.The need for online health services is currently increasing as well where the Covid-19 number is currently at its peak. Many people need self-isolation at home because hospitals lack treatment facilities. Online health services are needed by people who find it difficult to consult directly with health facilities.The Faculty of Medicine, Sriwijaya University (FK Unsri), especially the lecturers who are also health workers, initiated the formation of the Online Doctor Chat (CDO), as a response to the Covid-19 pandemic situation
Obesitas telah menjadi penyebab utama meningkatnya penyakit tidak menular. Penggunaan insentif finansial (FI) sangat mendorong gaya hidup sehat. Pola intervensi ini digunakan untuk mendorong perilaku hidup sehat yang bertujuan untuk mencegah dan mengelola penyakit kronis. Kebaruan penelitian ini yaitu meneliti secara meta analisis tentang kemanjuran pemeliharaan penurunan berat badan jangka pendek dengan intervensi insentif keuangan. Tujuan dari penelitian ini adalah untuk mengkonfirmasi perbedaan hasil antara studi, penelitian ini dilakukan untuk menguji efek keseluruhan dari studi menggunakan intervensi FI pada program penurunan berat badan. Metode yang digunakan adalah Database PubMed untuk mencari data. Data diambil dari studi yang melaporkan perubahan intervensi FI dengan hasil perubahan berat badan. Hasilnya menemukan bahwa 4 studi dengan obesitas dimasukkan. Hasil gabungan menunjukkan bahwa FI berpengaruh signifikan terhadap perubahan berat badan. Terdapat perbedaan peningkatan berat badan yang signifikan pada kelompok intervensi FI dibandingkan dengan kelompok kontrol (SMD: -3,37; CI 95%). Heterogenitas statistik ditemukan (I2 = 99,92%, P = 0,00). Kesimpulan hasil belum menunjukkan efek menguntungkan dari FI jangka pendek selama 3 bulan pada penurunan berat badan pada pasien obesitas. Namun, heterogenitas statistik ditemukan sehingga analisis subkelompok diperlukan.Kata kunci: penurunan berat badan; obesitas; insentif finansial. AbstractObesity has become a major etiology of the increase in non-communicable diseases. The use of financial incentives (FI) has greatly encouraged a healthy lifestyle. This intervention pattern is used to encourage healthy lifestyle behaviors aimed at preventing and managing chronic diseases. The novelty of this study is to examine the meta-analysis of the efficacy of maintaining short-term weight loss with financial incentive interventions. The aim of this study was to confirm differences in results between studies, this study was conducted to examine the overall effect of studies using FI interventions on weight loss programs. The method used is the PubMed Database to search for data. Data were drawn from studies reporting changes in the FI intervention with outcome changes in body weight. The results found that 4 studies with obesity were included. The combined results show that FI has a significant effect on changes in body weight. There was a significant difference in weight gain in the FI intervention group compared to the control group (SMD: -3.37; 95% CI). Statistical heterogeneity was found (I2 = 99.92%, P = 0.00). Conclusion the results have not shown a beneficial effect of short-term FI for 3 months on weight loss in obese patients. However, statistical heterogeneity was found so that a subgroup analysis was needed.
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