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Core-shell Fe 3 O 4 /Au nanostructures were constructed using an advanced method of two-step synthesis from Juglans regia (walnut) green husk extract. Several complementary methods were applied to investigate structural and magnetic properties of the samples. X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), electron diffraction, optical, thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM) were used for nanoparticle characterizations. As shown by HR-TEM, the mean diameter of core-shell Fe 3 O 4 /Au nanoparticles synthesized using co-precipitation method was 6.08 ± 1.06 nm. This study shows that the physical and structural properties of core-shell Fe 3 O 4 /Au nanoparticles possess intrinsic properties of gold and magnetite. VSM revealed that the core-shell Fe 3 O 4 /Au have high saturation magnetization and low coercivity due to the magnetic properties. The core-shell nanoparticles show the inhibitory concentration (IC) 50 of 235 μg/ml against a colorectal cancer cell line, HT-29. When tested against non-cancer cells, IC 50 was not achieved even up to 500 μg/ml. This study highlights the magnetic properties and anticancer action of coreshell Fe 3 O 4 /Au nanoparticles. This compound can be ideal candidate for cancer treatment and other biomedical applications.

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The good effects of swiftlet nest (SN) on the skin have been widely investigated. However, the importance of the SN in the area of nano-cosmeceutical research is still limited as it is commonly consumed, rather than being applied to the skin. Formulation and optimization processes are two important issues in the manufacturing of cosmetics. In this work, Response surface methodology (RSM) was utilized to investigate the influence of the nano-cosmeceuticals composition; purified SN (1-5% w/w), and Tween 80 (3-6% w/w) as well as the preparation method; time of homogenization (10-30 min), on the physicochemical properties of nano-cosmeceuticals. The response variables were particle size and zeta potential which were very important characteristics in nano-cosmeceuticals. Formulation and optimization of three independent variables were carried out to obtain an optimum nanocosmeceuticals with the lowest particle size and high stability formulation. The optimized nanoemulsion containing purified SN with particle size of 136.35 nm and zeta potential of À40.2 mV was successfully formulated. This was obtained experimentally and was closer to the predicted values of 136.22 nm and À40.07 mV, respectively. The optimized formulation remained stable for three months after the centrifugation test as well as storage at different temperatures of 4 C, 25 C and 45 C. View Article Onlinea A 0 is constant; A, B, C and D are the linear, regression coefficient for the linear effect; A 2 , B 2 and C 2 : regression coefficient for the quadratic effect; AB, AC and BC: regression coefficient for the interaction effect of the quadratic polynomial model. This journal is