Nothopanax Scutellarium (Araliaceae family), commonly known as the leaves of the bowl, is a medicinal plant that has many pharmacological properties. The leaves of this plant have various uses in traditional medicine for a number of diseases. There are so many substances contained in this plant such as flavonoids, saponins, tannins, phenolics, alkaloids, steroids and so on. Several studies have demonstrated the pharmacological exploration of Nothopanax Scutellarium as a Culex sp mosquito larvicide, diuretic, anti-kidney stone solubility, anti-aging, burn healer, anti-oxidant and anti-bacterial which were carried out experimentally both in vivo and in vitro.

Coleus scutellariodes (L), commonly known as Jawer kotok plant, is a medicinal plant that has many properties, one of which is as an immunodulator and some of its pharmacological activities. The leaves of this plant have various uses in traditional medicine for a number of diseases. Lots of substances contained in this plant such as flavonoids, saponins, tannins, alkaloids, steroids. One of the substances contained in jawer kotok leaves has efficacy as an immunodulator, namely flavonoids. Several studies have demonstrated the pharmacological exploration of Coleus scutellariodes (L) as an infectious disease (Tuberculosis), Anti-Inflammatory (vulvovaginal candidiasis), Antipyretic, Antioxidant-Active, Anti-diabetic, Anti-histamine, Anti-anthelmic. In this journal review, a comprehensive study focused on knowledge of plant functions as immunodulators, pharmacological activities and phytochemical studies of the jawer kotok plant Coleus scutellariodes (L).Keywords: Guides, instructions, author’s kit, conference publications.

Sunlight is an electromagnetic wave that plays a role in producing UV radiation. UV radiation is a major source of skin damage. The utilization of natural ingredients as active ingredients in sunscreen cosmetics is an alternative to chemicals that are also harmful to the skin. Several plants, including Brucea javanica (L.), Family Myrtaceae, Hippobroma Longiflora (L) G. Don, Kaempferia galanga L, and Eucheuma cottonii. Doty and Zea mays L. have the potential to be developed as a sunscreen.

Background: Medicine is a substance that through its chemical effects brings about changes in biological functions. The GRDDS delivery system is a sustained drug delivery system that can hold drugs back in the stomach for a longer time. The advantages of GRDDS include being able to increase bioavailability, increase the solubility of drugs that are poorly soluble in high pH, can control of therapeutic levels to reduce the occurrence of fluctuations, can extend the half-life so that the frequency of drug administration can be reduced.   Objectives: This study aims to describe the types of GRDDS preparations. The variation is due to a combination of differences in mechanisms and technology.   Method: The design in this study uses a systematic review of the review process that identifies, assesses, and interprets all findings on a research topic.   Result: Floating systems can use expandable polymeric materials such as HPMC and chitosan. The floating mechanism begins with the contact of gastric juices with tablets which causes the polymer to hydrate to form a gel layer that can withstand CO2 gas formed due to the interaction of sodium bicarbonate with citric acid so that the tablets can expand and can float.  The oral drug delivery route is the most preferred because it is easy to use. Absorption of oral drugs mostly occurs in the stomach and the intestines.   Conclusion: Therefore, it is necessary to have a drug delivery system that can extend the contact time with the stomach, namely the Gastroretentive Drug Delivery System (GRDDS).