Purpose To investigate the correlation between choroidal thickness and myopia progression using a deep learning method. Methods Two data sets, data set A and data set B, comprising of 123 optical coherence tomography (OCT) volumes, were collected to establish the model and verify its clinical utility. The proposed mask region-based convolutional neural network (R-CNN) model, trained with the pretrained weights from the Common Objects in Context database as well as the manually labeled OCT images from data set A, was used to automatically segment the choroid. To verify its clinical utility, the mask R-CNN model was tested with data set B, and the choroidal thickness estimated by the model was also used to explore its relationship with myopia. Results Compared with the result of manual segmentation in data set B, the error of the automatic choroidal inner and outer boundary segmentation was 6.72 ± 2.12 and 13.75 ± 7.57 µm, respectively. The mean dice coefficient between the region segmented by automatic and manual methods was 93.87% ± 2.89%. The mean difference in choroidal thickness over the Early Treatment Diabetic Retinopathy Study zone between the two methods was 10.52 µm. Additionally, the choroidal thickness estimated using the proposed model was thinner in high-myopic eyes, and axial length was the most significant predictor. Conclusions The mask R-CNN model has excellent performance in choroidal segmentation and quantification. In addition, the choroid of high myopia is significantly thinner than that of nonhigh myopia. Translational Relevance This work lays the foundations for mask R-CNN models that could aid in the evaluation of more intricate changes occurring in chorioretinal diseases.

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