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A convenient and efficient protocol has been developed for the synthesis of 2‐aroylindoles (3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j) in good yields by the reaction of 2‐aminoketones (1a, 1b, 1c) with phenacyl bromides (2a, 2b, 2c, 2d). The reaction success varied with different bases and solvents in both conventional and microwave methods. But finally, it was established that piperidine in DMF was an effective medium to carry out the reaction under microwave irradiation conditions.

Synthesis, Antibacterial and Antiinflammatory Activity of Bis(indolyl)methanes.-A series of bioactive bis(indolyl)methanes (III) is formed by a one-pot green reaction of indole with substituted aldehydes under microwave irradiation and solvent--free conditions. The majority of these compounds shows good antibacterial and antiinflammatory activity. Interestingly, the compounds (IIIb)-(IIIe) exhibit even a higher antiinflammatory activity than the standard drug diclofenac. -(SARVA, S.; HARINATH, J. S.; STHANIKAM, S. P.; ETHIRAJ, S.; VAITHIYALINGAM, M.; CIRANDUR*, S. R.; Chin. Chem. Lett. 27 (2016) 1, 16-20, http://dx.

by reaction of aminoketones with phenacyl bromides