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A variety of pyrimidinyl benzothiazine carboxamides were prepared from benzothiazine carboxylate and 4,6‐diaryl/heteroarylpyrimidinyl‐2‐amines. The compounds having 4‐nitro phenyl, 4‐pyridinyl and pyrazolyl ‐ pyrimidinyl benzothiazine carboxamide moieties 6 e, 6 i, 6 j, 6 k and 6 m displayed prominent antibacterial activity against Bacillus subtilis. Further, compounds having pyrrolyl, pyrazolyl, pyridinyl and indolyl units 6 f, 6 k, 6 m and 6 n displayed prominent antifungal activity against Aspergillus niger. On the other hand, compounds with electron donating substituents on the aromatic ring (6 b, 6 c) and those with furan moiety (6 g, 6 h and 6 l) displayed very good free radical scavenging activity greater than Ascorbic acid.

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