It is concluded that, although some domains might need to be examined further, the Xhosa EQ-5D is a valid and reliable instrument with which to determine HRQoL in an urban Xhosa speaking population. In order to ensure validity of results in multicultural research and drug trials, it is essential that more outcome measures are subjected to rigorous translation and testing of validity and reliability.

Despite being asked specifically to answer the questions in relation to their health status, the participants apparently did not differentiate between general quality of life (QoL) and specific HRQoL. It appears that members of an underresourced community regard socioeconomic and service delivery aspects of their lives as integral to their perceived state of health. It may be that it is not possible to separate out factors relating to general QoL from those specifically related to HRQoL in an underresourced population, and such populations might not be suitable for inclusion in certain clinical trials where an improvement in HRQoL is the required outcome. Alternatively, if an HRQoL instrument is to be used to monitor the impact of medical interventions, the inclusion of Environmental Factors should be considered.

Despite being asked specifically to answer the questions in relation to their health status, the participants apparently did not differentiate between general quality of life (QoL) and specific HRQoL. It appears that members of an under-resourced community regard socioeconomic and service delivery aspects of their lives as integral to their perceived state of health. It may be that it is not possible to separate factors relating to general quality of life from those specifically related to HRQoL in an under-resourced population and such populations might not be suitable for inclusion in certain clinical trials where improvement in HRQoL is the required outcome. Alternatively, if a HRQoL instrument is to be used to monitor the impact of medical intervention, the inclusion of environmental factors should be considered.