COVID-19 was first reported in China's Wuhan city of Hubei province in late 2019. The World Health Organization (WHO) declared it a global public health emergency and a global pandemic respectively in quick succession as it spread so fast across the world. In this chapter, the authors analyze its effects on Zambia by focusing on among others, the economy, education, family interactions, culture, and psychosocial wellbeing of Zambia and how the government responded to minimize the effects. They find that preventive measures were not fully adhered to in many places partly because the government did not enforce a total lockdown as many other countries did although learning institutions, drinking places, church gatherings, funeral processions, and other social gatherings such as weddings were all suspended. They note that government responses to the pandemic preserved lives but also worsened the economic slowdown. They conclude that the pandemic exposed the deficiencies in the healthcare and social protection systems and inequality in the country but enhanced digitalization.