The discovery of new chemotherapeutics with novel bioactivities and functionalities to fight current emerging diseases has become the most significant research in pharmaceutical science. Schiff bases are versatile pharmacophores that can form complexes by chelation with metals of different oxidation states. Over a few decades of intensive research on metal-based drugs, Schiff base metal complexes have been considered as the active field of research in coordination chemistry, owing to their valuable applications in various fields of science. As therapeutic drugs, they have potential applications as antibiotic, antimicrobial, antitumor, antiviral, anti-inflammatory, analgesic, antifungal, and many more. There has been a global threat of drug resistance in medical science in recent years because most of the pathogenic organisms are developing the ability to deactivate drug substances. For this reason, it requires urgent attention from chemical and pharmaceutical scientists to address the severe challenges of multidrug resistance. This review summarizes the current developments in the last few decades' research on the chemotherapeutic activities of Schiff base metal complexes. BIBECHANA 18 (2021) 214-230

The COVID-19 pandemic caused by SARS-CoV-2 has become a global public health concern. Recently, vaccines have been developed to treat this infectious disease. However, these newly developed vaccines are not widely available and not suitable for all age groups. In such circumstances, it is wise to wear personal protective equipment (PPE) such as masks, gloves, and gowns to better protect against COVID-19. Face masks have long been recommended as a means of preventing respiratory infections. However, inappropriate use of masks may undermine their effectiveness. The antimicrobial and antiviral properties of graphene have sparked interest in the development of medical devices such as face masks, gloves, and gowns with extra filtering ability to curb the effects of the coronaviruses. Their hydrophobicity, nanosize, large surface area, high electrical and thermal conductivities, and virulence are notable features that reduce the transmission of viruses from person to person via respiratory routes. Graphene-enhanced face masks are intended to encourage travelers to wear them at work and during recreational activities. Moreover, graphene can pose health hazards if inhaled during respiration. In this review, we summarize the current status of graphene and its promising applications for combating COVID-19. Additionally, this review aims to explore the quality of this biomaterial and possible suggestions for the better and safer use of graphene structured respirators.

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