<b><i>Background:</i></b> Hemodialysis therapy has been used in the treatment of acute alcohol intoxication for many years, especially acute severe alcohol intoxication. <b><i>Objectives:</i></b> This study aimed to evaluate whether the combination of conventional treatment and naloxone with hemodialysis has advantages over conventional treatment and naloxone alone in patients with acute severe alcohol intoxication. <b><i>Methods:</i></b> After searching 12 databases and 2 clinical trial centers. According to the established inclusion and exclusion criteria, the qualified literatures were screened. The outcome indicators were length of hospital stay, coma time, time of symptom disappearance, the overall complication rate, the incidence of pancreatitis, the incidence of aspiration pneumonia, the incidence of hepatic and renal dysfunction. Analysis was performed using Revman 5.3. <b><i>Results:</i></b> This meta-analysis included 13 studies, including 932 subjects. In the treatment of acute severe alcohol intoxication, the use of hemodialysis on the basis of conventional treatment and naloxone could reduce the length of hospital stay (WMD = −15.16, 95% CI: −17.45 to −12.86, <i>p</i> &#x3c; 0.001) in hours and (WMD = −4.89, 95% CI: −5.53 to −4.25, <i>p</i> &#x3c; 0.001) in days; coma time (WMD = −5.43, 95% CI: −6.43 to −4.43, <i>p</i> &#x3c; 0.001); time of symptom disappearance (WMD = −3.92, 95% CI: −5.37 to −2.47, <i>p</i> &#x3c; 0.001); the overall complication rate (RR = 0.39, 95% CI: 0.28–0.55, <i>p</i> &#x3c; 0.001); the incidence of pancreatitis (RR = 0.14, 95% CI: 0.05–0.43, <i>p</i> = 0.0006); the incidence of aspiration pneumonia (RR = 0.15, 95% CI: 0.04–0.66, <i>p</i> = 0.01), and the incidence of hepatic and renal dysfunction (RR = 0.21, 95% CI: 0.06–0.72, <i>p</i> = 0.01). <b><i>Conclusions:</i></b> It can be concluded that compared with the use of conventional treatment and naloxone alone, the use of hemodialysis on the basis of conventional treatment and naloxone for acute severe alcohol intoxication can reduce the length of hospital stay, coma time, time of symptom disappearance, and the incidence of some complications rate. Large scale, multicenter, and well-designed RCTs are needed in the future to prove our conclusions.

Review question / Objective: This meta-analysis aims to explore whether damage control surgery has advantages over traditional surgery in the treatment of multiple trauma. Information sources: The Chinese Biomedical literature (CBM), Chinese National Knowledge Infrastructure (CNKI), Weipu (VIP), Duxiu, WanFang, Web of sciense, PubMed, Scopus, Ovid, EMbase, ProQuest, Cochrane, Chinese clinical trial Registry and Clinical Trials.gov databases. Main outcome(s): mortality rate, the success rate of rescue, In-hospital length of stay, ICU length of stay, the overall incidence rate of complications, incidence of disseminated intravascular coagulation (DIC), incidence of multiple organ dysfunction syndrome (MODS) , incidence of shock.

BackgroundAcute severe organophosphorus pesticide poisoning is a common severe emergency in developing countries. Our meta-analysis aimed to clarify the efficacy of hemoperfusion combined with hemodialysis on acute severe organophosphorus pesticide poisoning.MethodsSeveral databases were searched. After formulating relevant inclusion and exclusion criteria, qualified studies were included, and the data were extracted. The outcome indicators were the success rate of rescue, the time of hospitalization, the incidence of complications, the time for the cholinesterase level to return to normal, the coma time, and the atropine dosage. The results were analyzed using risk ratios, weighted mean difference, standard mean difference, and 95% confidence interval. The Cochrane Collaboration tool was used to assess the risk of bias in all the included studies. In terms of statistical methods, we used RevMan software (version 5.3; The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) and Stata (versions 14 and 16; StataCorp, College Station, TX, USA) for the data analysis.ResultsWe included 92 randomized controlled trials with 6899 participants. Compared with the conventional emergency treatment group (CET group), the hemoperfusion group (HP + CET group), and the hemodialysis group (HD + CET group), the use of hemoperfusion combined with hemodialysis based on CET (HP + HD + CET group) significantly increased the success rate of rescue and reduced hospitalization time, the incidence of complications, time for cholinesterase level to return to normal, coma time, and atropine dosage.ConclusionHemoperfusion combined with hemodialysis is effective in the treatment of acute severe organophosphorus pesticide poisoning. In the future, more scientifically designed, large-scale, high-quality, multicenter randomized controlled trials are needed to validate this study further.

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