Some aspects of the clinical anatomy of the mandibular and maxillofacial regions of the west african dwarf goat in Nigeria. Int. J. Morphol., 23(1):33-36, 2005.SUMMARY: Some measurements in the mandibles and upper jaws of thirty West African Dwarf (WAD) goats without any apparent skeletal disorders were analysed. The length and height of the mandibles were 12.00 cm and 6.90 cm, respectively. The distance from the lateral alveolar root to the mental foramen, from the mental foramen to the caudal mandibular border were 1.56cm, 9.96cm, and 2.58cm respectively. The width and height of the mental foramen were 0.5 cm and 0.3 cm, respectively. These data are discussed with regard to their application to clinical manoeuvres around the head of the goat such as regional anesthesia during dental extraction.OLOPADE, J. O. & ONWUKA, S. K. Aspectos de anatomía clínica de las regiones mandibular y maxilofacial de la cabra enana del oeste africano en Nigeria. Int. J. Morphol., 23(1):33-36, 2005. RESUMEN: Fueron analizadas algunas medidas en la mandíbula y maxila de treinta cabras enanas, del Oeste de Africa (WAD) sin desórdenes esqueléticos aparentes. La longitud y altura de la mandíbula fueron 12,0 cm y 6,9 cm, respectivamente. Las distancias desde la raiz alveolar lateral al foramen mental y desde este último al margen inferior de la mandíbula, fueron 1,56 cm y 2,58 cm, respectivamente. El ancho y altura del foramen mental fueron 0,5 cm y 0,3 cm, respectivamente. Estos datos son discutidos considerando las maniobras de aplicación clínica realizadas en la cabeza de la cabra, como también con los procedimientos de anestesia regional durante la extracción dental.

Environmental exposure to vanadium occurs in areas of persistent burning of fossil fuels; this metal is known to induce oxidative stress and oligodendrocyte damage. Here, we determined whether vanadium exposure (3 mg/kg) in mice during the first 3 postnatal months leads to a sustained neuroinflammatory response. Body weight monitoring, and muscle strength and open field tests showed reduction of body weight gain and locomotor impairment in vanadium-exposed mice. Myelin histochemistry and immunohistochemistry for astrocytes, microglia, and nonphosphorylated neurofilaments revealed striking regional heterogeneity. Myelin damage involved the midline corpus callosum and fibers in cortical gray matter, hippocampus, and diencephalon that were associated with axonal damage. Astrocyte and microglial activation was identified in the same regions and in the internal capsule; however, no overt myelin and axon damage was observed in the latter. Double immunofluorescence revealed induction of high tumor necrosis factor (TNF) immunoreactivity in reactive astrocytes. Western blotting analysis showed significant induction of TNF and interleukin-1β expression. Together these findings show that chronic postnatal vanadium exposure leads to functional deficit and region-dependent myelin damage that does not spare axons. This injury is associated with glial cell activation and proinflammatory cytokine induction, which may reflect both neurotoxic and neuroprotective responses.

Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system. This work was designed to assess memory deficits in mice chronically exposed to vanadium. A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into three major groups of vanadium treated, matched controls, and animals exposed to vanadium for three months and thereafter vanadium was withdrawn. Animals were tested using Morris water maze and forelimb grip test at 3, 6, 9, and 12 months of age. The results showed that animals across the groups showed no difference in learning but had significant loss in memory abilities after 3 months of vanadium exposure and this trend continued in all vanadium-exposed groups relative to the controls. Animals exposed to vanadium for three months recovered significantly only 9 months after vanadium withdrawal. There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and the controls in all age groups. In conclusion, we have shown that chronic administration of vanadium in mice leads to memory deficit which is reversible but only after a long period of vanadium withdrawal.

The primary and secondary responses in the skin of specific pathogen free (SPF) lambs to scarification and orf virus infection were studied and the temporal changes in numbers of dermal polymorphonuclear and mast cells were examined. The clinical and histopathological changes after primary infection were similar to those previously described after secondary infection although there was a more severe reaction and an increased timescale. It is concluded that relevant data on the cellular processes involved in the host response to orf virus can be obtained from previously infected animals. Two stages of cutaneous response were identified histologically; (i) repair of the injury and (ii) reaction to virus replication, which, as determined by antigen location, initially seemed to occur within the newly repaired epidermis. The second stage comprised a localised inflammatory response and epidermal proliferation beneath it, resulting in isolation of the infected zone . The response involved neutrophils, basophils and possibly mast cells but not eosinophils.